Institution
University of Oviedo
Education•Oviedo, Spain•
About: University of Oviedo is a education organization based out in Oviedo, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 13423 authors who have published 31649 publications receiving 844799 citations. The organization is also known as: Universidá d'Uviéu & Universidad de Oviedo.
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TL;DR: The experimental data and simulations suggest a nonresonant tunneling mechanism involving hole transport through the molecular HOMO, with a decay constant β = 3.4 ± 0.1 nm(-1) and a contact resistance R(c) = 40 kΩ per Au-S bond.
Abstract: The charge transport characteristics of 11 tailor-made dithiol-terminated oligo(phenylene-ethynylene) (OPE)-type molecules attached to two gold electrodes were studied at a solid/liquid interface in a combined approach using an STM break junction (STM-BJ) and a mechanically controlled break junction (MCBJ) setup We designed and characterized 11 structurally distinct dithiol-terminated OPE-type molecules with varied length and HOMO/LUMO energy Increase of the molecular length and/or of the HOMO-LUMO gap leads to a decrease of the single-junction conductance of the linearly conjugate acenes The experimental data and simulations suggest a nonresonant tunneling mechanism involving hole transport through the molecular HOMO, with a decay constant β = 34 ± 01 nm(-1) and a contact resistance R(c) = 40 kΩ per Au-S bond The introduction of a cross-conjugated anthraquinone or a dihydroanthracene central unit results in lower conductance values, which are attributed to a destructive quantum interference phenomenon for the former and a broken π-conjugation for the latter The statistical analysis of conductance-distance and current-voltage traces revealed details of evolution and breaking of molecular junctions In particular, we explored the effect of stretching rate and junction stability We compare our experimental results with DFT calculations using the ab initio code SMEAGOL and discuss how the structure of the molecular wires affects the conductance values
277 citations
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TL;DR: It is concluded that the seven identified ADAMTS genes, with at least 18 distinct members encoded within the human genome, represent an example of a widely expanded protease family during metazoan evolution.
276 citations
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Paris Descartes University1, University of Texas Health Science Center at San Antonio2, Carlos III Health Institute3, French Institute of Health and Medical Research4, University of Oviedo5, University of Brescia6, Leiden University7, Pierre-and-Marie-Curie University8, Maastricht University9, University of Rennes10, Erasmus University Rotterdam11, Radboud University Nijmegen12, University of Nantes13, National Institutes of Health14, Beijing Genomics Institute15, University of Florence16, University of Michigan17, Ludwig Maximilian University of Munich18, University of Franche-Comté19
TL;DR: Germline mutations in MAX are responsible for 1.12% of PCC/PGL in patients without evidence of other known mutations and should be considered in the genetic work-up of these patients.
Abstract: PURPOSE: Pheochromocytomas (PCC) and paragangliomas (PGL) are genetically heterogeneous neural crest-derived neoplasms. Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X), which predisposes carriers to PCC. How MAX mutations contribute to PCC/PGL and associated phenotypes remain unclear. This study aimed to examine the prevalence and associated phenotypic features of germline and somatic MAX mutations in PCC/PGL. Design: We sequenced MAX in 1,694 patients with PCC or PGL (without mutations in other major susceptibility genes) from 17 independent referral centers. We screened for large deletions/duplications in 1,535 patients using a multiplex PCR-based method. Somatic mutations were searched for in tumors from an additional 245 patients. The frequency and type of MAX mutation was assessed overall and by clinical characteristics. RESULTS: Sixteen MAX pathogenic mutations were identified in 23 index patients. All had adrenal tumors, including 13 bilateral or multiple PCCs within the same gland (P < 0.001), 15.8% developed additional tumors at thoracoabdominal sites, and 37% had familial antecedents. Age at diagnosis was lower (P = 0.001) in MAX mutation carriers compared with nonmutated cases. Two patients (10.5%) developed metastatic disease. A mutation affecting MAX was found in five tumors, four of them confirmed as somatic (1.65%). MAX tumors were characterized by substantial increases in normetanephrine, associated with normal or minor increases in metanephrine. CONCLUSIONS: Germline mutations in MAX are responsible for 1.12% of PCC/PGL in patients without evidence of other known mutations and should be considered in the genetic work-up of these patients.
276 citations
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TL;DR: In this article, results of searches for heavy stable charged particles produced in pp collisions at 7 and 8 TeV are presented corresponding to an integrated luminosity of 5.0 and 18.8 inverse femtobarns, respectively.
Abstract: Results of searches for heavy stable charged particles produced in pp collisions at sqrt(s) = 7 and 8 TeV are presented corresponding to an integrated luminosity of 5.0 inverse femtobarns and 18.8 inverse femtobarns, respectively. Data collected with the CMS detector are used to study the momentum, energy deposition, and time-of-flight of signal candidates. Leptons with an electric charge between e/3 and 8e, as well as bound states that can undergo charge exchange with the detector material, are studied. Analysis results are presented for various combinations of signatures in the inner tracker only, inner tracker and muon detector, and muon detector only. Detector signatures utilized are long time-of-flight to the outer muon system and anomalously high (or low) energy deposition in the inner tracker. The data are consistent with the expected background, and upper limits are set on the production cross section of long-lived gluinos, scalar top quarks, and scalar tau leptons, as well as pair produced long-lived leptons. Corresponding lower mass limits, ranging up to 1322 GeV for gluinos, are the most stringent to date.
276 citations
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TL;DR: This article showed that matriptase-2 activity represents a novel and relevant step in hepcidin regulation and iron homeostasis in Tmprss6(-/-) mice.
275 citations
Authors
Showing all 13643 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Carlo Rovelli | 146 | 1502 | 103550 |
J. González-Nuevo | 144 | 500 | 108318 |
German Martinez | 141 | 1476 | 107887 |
Roland Horisberger | 139 | 1471 | 100458 |
Francisco Herrera | 139 | 1001 | 82976 |
Javier Cuevas | 138 | 1689 | 103604 |
Teresa Rodrigo | 138 | 1831 | 103601 |
L. Toffolatti | 136 | 376 | 95529 |
Elias Campo | 135 | 761 | 85160 |
Gabor Istvan Veres | 135 | 1349 | 96104 |
Francisco Matorras | 134 | 1428 | 94627 |
Joe Incandela | 134 | 1549 | 93750 |
Nikhil C. Munshi | 134 | 906 | 67349 |
Luca Scodellaro | 134 | 1741 | 98331 |