Institution
University of South Australia
Education•Adelaide, South Australia, Australia•
About: University of South Australia is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 10086 authors who have published 32587 publications receiving 913683 citations. The organization is also known as: The University of South Australia & UniSA.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The results suggest that tactile acuity is diminished in arthritis, complex regional pain syndrome, and chronic low back pain but not in burning mouth syndrome and that tactile Acuity training may benefit those with chronic pain disorders, and suggests that clinical trials may be warranted.
171 citations
••
TL;DR: An important remedial method for marine oil pollution treatment—bioremediation technique—is introduced, considered as a reliable, efficient, cost-effective, and eco-friendly method.
Abstract: Due to the toxicity of petroleum compounds, the increasing accidents of marine oil spills/leakages have had a significant impact on our environment. Recently, different remedial techniques for the treatment of marine petroleum pollution have been proposed, such as bioremediation, controlled burning, skimming, and solidifying. (Hedlund and Staley in Int J Syst Evol Microbiol 51:61-66, 2001). This review introduces an important remedial method for marine oil pollution treatment-bioremediation technique-which is considered as a reliable, efficient, cost-effective, and eco-friendly method. First, the necessity of bioremediation for marine oil pollution was discussed. Second, this paper discussed the species of oil-degrading microorganisms, degradation pathways and mechanisms, the degradation rate and reaction model, and the factors affecting the degradation. Last, several suggestions for the further research in the field of marine oil spill bioremediation were proposed.
171 citations
••
171 citations
••
TL;DR: In this article, the problem of finding an energy-efficient driving strategy for a train journey on an undulating track with steep grades subject to a maximum prescribed journey time was discussed.
Abstract: We discuss the problem of finding an energy-efficient driving strategy for a train journey on an undulating track with steep grades subject to a maximum prescribed journey time. In Part 1 of this paper we reviewed the state-of-the-art and established the key principles of optimal train control for a general model with continuous control. We assumed only that the tractive and braking control forces were bounded by non-increasing speed-dependent magnitude constraints and that the rate of energy dissipation from frictional resistance was given by a non-negative strictly convex function of speed. Partial cost recovery from regenerative braking was allowed. Our aim was to minimize the mechanical energy required to drive the train. We examined the characteristic optimal control modes, studied allowable control transitions and established the existence of optimal switching points. We found algebraic formulae for the adjoint variables in terms of speed on track with piecewise-constant gradient and drew phase plots of the associated optimal evolutionary lines for the state and adjoint variables. In Part 2 we will establish integral forms of the necessary conditions for optimal switching, find general bounds on the positions of the optimal switching points, justify an extended local energy minimization principle and show how these ideas can be used to calculate the optimal strategy. We prove that an optimal strategy always exists and use a perturbation analysis to show that the optimal strategy is unique. Finally we discuss computation of optimal switching points in two realistic examples with steep grades and describe the optimal control strategies and corresponding speed profiles for a complete journey with several different allowed journey times. In practice the strategies described here have been shown to reduce the costs of energy used by as much as 20%.
171 citations
••
TL;DR: The present work suggests that peripheral Aβ clearance is a valid therapeutic approach for AD, and implies that deficits in the A β clearance in the periphery might also contribute to AD pathogenesis.
Abstract: Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its therapeutic potential for AD remains largely unknown. Here, we measured blood Aβ levels in different locations of the circulation in humans and mice, and used a parabiosis model to investigate the effect of peripheral Aβ catabolism on AD pathogenesis. We found that blood Aβ levels in the inferior/posterior vena cava were lower than that in the superior vena cava in both humans and mice. In addition, injected (125)I labeled Aβ40 was located mostly in the liver, kidney, gastrointestinal tract, and skin but very little in the brain; suggesting that Aβ derived from the brain can be cleared in the periphery. Parabiosis before and after Aβ deposition in the brain significantly reduced brain Aβ burden without alterations in the expression of amyloid precursor protein, Aβ generating and degrading enzymes, Aβ transport receptors, and AD-type pathologies including hyperphosphorylated tau, neuroinflammation, as well as neuronal degeneration and loss in the brains of parabiotic AD mice. Our study revealed that the peripheral system is potent in clearing brain Aβ and preventing AD pathogenesis. The present work suggests that peripheral Aβ clearance is a valid therapeutic approach for AD, and implies that deficits in the Aβ clearance in the periphery might also contribute to AD pathogenesis.
170 citations
Authors
Showing all 10298 results
Name | H-index | Papers | Citations |
---|---|---|---|
Andrew P. McMahon | 162 | 415 | 90650 |
Timothy P. Hughes | 145 | 831 | 91357 |
Jeremy K. Nicholson | 141 | 773 | 80275 |
Peng Shi | 137 | 1371 | 65195 |
Daniel Thomas | 134 | 846 | 84224 |
Jian Li | 133 | 2863 | 87131 |
Matthew Jones | 125 | 1161 | 96909 |
Ulrich S. Schubert | 122 | 2229 | 85604 |
Elaine Holmes | 119 | 560 | 58975 |
Arne Astrup | 114 | 866 | 68877 |
Richard Gray | 109 | 808 | 78580 |
John B. Furness | 103 | 597 | 37668 |
Thomas J. Jentsch | 101 | 238 | 32810 |
Ben W.J. Mol | 101 | 1485 | 47733 |
John C. Lindon | 99 | 488 | 44063 |