University of South Australia

About: University of South Australia is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 10086 authors who have published 32587 publications receiving 913683 citations. The organization is also known as: The University of South Australia & UniSA.

Fate of ZnO nanoparticles in soils and cowpea (Vigna unguiculata).

Abstract: The increasing use of zinc oxide nanoparticles (ZnO-NPs) in various commercial products is prompting detailed investigation regarding the fate of these materials in the environment. There is, however, a lack of information comparing the transformation of ZnO-NPs with soluble Zn2+ in both soils and plants. Synchrotron-based techniques were used to examine the uptake and transformation of Zn in various tissues of cowpea (Vigna unguiculata (L.) Walp.) exposed to ZnO-NPs or ZnCl2 following growth in either solution or soil culture. In solution culture, soluble Zn (ZnCl2) was more toxic than the ZnO-NPs, although there was substantial accumulation of ZnO-NPs on the root surface. When grown in soil, however, there was no significant difference in plant growth and accumulation or speciation of Zn between soluble Zn and ZnO-NP treatments, indicating that the added ZnO-NPs underwent rapid dissolution following their entry into the soil. This was confirmed by an incubation experiment with two soils, in which ZnO-NP...

Understanding and managing employability in changing career contexts

Abstract: Purpose – The purpose of this paper is to explore the concept of employability as it has evolved over time and to propose a new definition which reflects the critical variables that contribute to employability at an individual level It also offers suggestions for how to manage employability and careers at both an individual and an organisational levelDesign/methodology/approach – The paper reviews the literature on employability It considers why employability has become a topic of interest, examines how the concept has evolved over time, and seeks to develop a working definition It suggests a range of practical strategies for individual and organisations to ensure that employability is managed successfullyFindings – Employability is as dependent on context as on the individual Therefore the current emphasis on individual responsibility for employability needs to be re‐examined and a greater emphasis placed on how organisations can support employees to manage careers and employability This shift in

Expressed Readiness of Australian Schoolchildren to Act as Bystanders in Support of Children who are Being Bullied

Abstract: Promoting interventive action on the part of student bystanders witnessing peer victimisation is currently seen as a promising way of reducing bullying in schools. A video depicting bullying in the presence of bystanders was viewed by late primary (n = 200) and early secondary school students (n = 200). Some 43% of the students indicated that they were likely to help the victim. Questionnaires were employed to assess student attitudes towards victims, beliefs about the expectations of parents, friends, and teachers, perceived self‐efficacy, and social desirability response set. Multiple regression analysis identified as significant predictors of expressed intention to intervene: attending primary school, having rarely or never bullied others, having (reportedly) previously intervened, positive attitude to victims, and believing that parents and friends (but not teachers) expected them to act to support victims. Implications for action to reduce bullying in schools are discussed.

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Abstract: The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibroblasts (CAFs) to provide a supportive niche for the acquisition of a chemo-resistant, cancer stem cell (CSC) phenotype via FGF5 expression and production of fibrillar collagen. Stromal treatment of patient-derived xenografts with smoothened inhibitors (SMOi) downregulates CSC markers expression and sensitizes tumors to docetaxel, leading to markedly improved survival and reduced metastatic burden. In the phase I clinical trial EDALINE, 3 of 12 patients with metastatic TNBC derived clinical benefit from combination therapy with the SMOi Sonidegib and docetaxel chemotherapy, with one patient experiencing a complete response. These studies identify Hedgehog signaling to CAFs as a novel mediator of CSC plasticity and an exciting new therapeutic target in TNBC.