A striking organization of a large family of human neural cadherin-like cell adhesion genes.
Qiang Wu,Tom Maniatis +1 more
TLDR
Comparison of the genomic DNA sequences with those of representative cDNAs reveals a striking genomic organization similar to that of immunoglobulin and T cell receptor gene clusters, which has interesting implications regarding the molecular code required to establish complex networks of neuronal connections in the brain and the mechanisms of cell-specific cadherin-like gene expression.About:
This article is published in Cell.The article was published on 1999-06-11 and is currently open access. It has received 693 citations till now. The article focuses on the topics: genomic DNA & Protocadherin.read more
Citations
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Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
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Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
Dietmar Schmucker,James C. Clemens,James C. Clemens,Huidy Shu,Carolyn A. Worby,Jian Xiao,Marco Muda,Jack E. Dixon,S. Lawrence Zipursky +8 more
TL;DR: CDNA and genomic analyses reveal the existence of multiple forms of Dscam with a conserved architecture containing variable Ig and transmembrane domains, which may contribute to the specificity of neuronal connectivity.
Journal ArticleDOI
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
TL;DR: How different members of the cadherin family act in different developmental contexts is examined, and the mechanisms involved are discussed.
Journal ArticleDOI
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function
Ya Guo,Quan Xu,Quan Xu,Daniele Canzio,Jia Shou,Jia Shou,Li Jinhuan,Li Jinhuan,David U. Gorkin,Inkyung Jung,Haiyang Wu,Haiyang Wu,Yanan Zhai,Yanan Zhai,Yuanxiao Tang,Yuanxiao Tang,Yichao Lu,Yichao Lu,Yonghu Wu,Yonghu Wu,Zhilian Jia,Zhilian Jia,Wei Li,Wei Li,Michael Q. Zhang,Bing Ren,Adrian R. Krainer,Tom Maniatis,Qiang Wu,Qiang Wu +29 more
TL;DR: Although enhancers can function in an orientation-independent manner in reporter assays, in the native chromosome context, the orientation of at least some enhancers carrying CBSs can determine both the architecture of topological chromatin domains and enhancer/promoter specificity.
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Protein function in the post-genomic era
TL;DR: Faced with the avalanche of genomic sequences and data on messenger RNA expression, biological scientists are confronting a frightening prospect: piles of information but only flakes of knowledge as mentioned in this paper, which is a problem in the field of functional genomics.
References
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Stephen F. Altschul,Thomas L. Madden,Alejandro A. Schäffer,Jinghui Zhang,Zheng Zhang,Webb Miller,David J. Lipman +6 more
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TL;DR: A coupling between physical adhesion and developmental signaling provides a mechanism to tightly integrate physical aspects of tissue morphogenesis with cell growth and differentiation, a coordination that is essential to achieve the intricate patterns of cells in tissues.
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Cadherin cell adhesion receptors as a morphogenetic regulator
TL;DR: Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells and play a role in cell sorting mechanisms, conferring adhesion specificities on cells.
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Morphogenetic roles of classic cadherins
TL;DR: Classic cadherins, which are known to be crucial for homotypic cell-cell adhesion, have been found to be present not only in vertebrate but also in invertebrate species.
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Cadherins: A Molecular Family Important in Selective Cell-Cell Adhesion
TL;DR: This paper presents a meta-analyses of cDNA transference studies on CADherin FUNCTION and discusses the role of CADherins 1N MORPHOGENESIS in this research.