Blautia faecis sp. nov., isolated from human faeces.
TLDR
Based on the phenotypic, genotypic and phylogenetic characteristics presented in this study, strain M25(T) represents a novel species within the genus Blautia for which the name BlautIA faecis sp.Abstract:
A strictly anoxic, Gram-stain-positive, non-motile
Blautia
-like bacterium, designated strain M25T, was isolated from a human faecal sample. Strain M25T was negative for both catalase and oxidase activity, utilized carbohydrates as fermentable substrates, produced lactate and acetate as the major end products of glucose fermentation in PYG medium, and had a DNA G+C content of 41.6 mol%. Comparative 16S rRNA gene sequencing showed that strain M25T was closely related to
Ruminococcus obeum
ATCC 29174T (96.40 % 16S rRNA gene sequence similarity) and
Blautia glucerasea
HFTH-1T (96.17 %) within the family
Lachnospiraceae
. Straight-chain saturated and monounsaturated cellular fatty acids were also detected, the majority being C14 : 0, C16 : 0 and C16 : 0 dimethyl acetal acids. Based on the phenotypic, genotypic and phylogenetic characteristics presented in this study, strain M25T represents a novel species within the genus
Blautia
for which the name Blautia faecis sp. nov. is proposed. The type strain is M25T ( = KCTC 5980T = JCM 17205T).read more
Citations
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Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease
Robert R. Jenq,Robert R. Jenq,Ying Taur,Ying Taur,Sean M. Devlin,Doris M. Ponce,Doris M. Ponce,Jenna D. Goldberg,Jenna D. Goldberg,Katya F. Ahr,Eric R. Littmann,Lilan Ling,Asia Gobourne,Liza Miller,Melissa D. Docampo,Jonathan U. Peled,Jonathan U. Peled,Nicholas Arpaia,Justin R. Cross,Tatanisha Peets,Melissa Lumish,Yusuke Shono,Jarrod A Dudakov,Hendrik Poeck,Alan M. Hanash,Alan M. Hanash,Juliet N. Barker,Juliet N. Barker,Miguel-Angel Perales,Miguel-Angel Perales,Sergio Giralt,Sergio Giralt,Eric G. Pamer,Eric G. Pamer,Marcel R.M. van den Brink,Marcel R.M. van den Brink +35 more
TL;DR: It is concluded that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival.
Journal ArticleDOI
Blautia-a new functional genus with potential probiotic properties?
Xuemei Liu,Mao Bingyong,Jiayu Gu,Jiaying Wu,Cui Shumao,Wang Gang,Jianxin Zhao,Hao Zhang,Wei Chen +8 more
TL;DR: Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the feces and intestines of mammals as discussed by the authors based on phenotypic and phylogenetic analyses.
Journal ArticleDOI
Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial
Yi Wan,Fenglei Wang,Jihong Yuan,Jie Li,Dandan Jiang,Jingjing Zhang,Hao Li,Ruoyi Wang,Jun Tang,Tao Huang,Ju-Sheng Zheng,Andrew J. Sinclair,Jim Mann,Duo Li +13 more
TL;DR: Higher-fat consumption by healthy young adults whose diet is in a state of nutrition transition appeared to be associated with unfavourable changes in gut microbiota, faecal metabolomic profiles and plasma proinflammatory factors, which might confer adverse consequences for long-term health outcomes.
Journal ArticleDOI
Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial.
Xiaolin Tong,Jia Xu,Fengmei Lian,Xiaotong Yu,Xiaotong Yu,Yufeng Zhao,Lipeng Xu,Menghui Zhang,Xiyan Zhao,Xiyan Zhao,Jian Shen,Shengping Wu,Shengping Wu,Xiaoyan Pang,Jiaxing Tian,Jiaxing Tian,Chenhong Zhang,Qiang Zhou,Linhua Wang,Bing Pang,Feng Chen,Zhiping Peng,Jing Wang,Zhong Zhen,Chao Fang,Min Li,Limei Chen,Liping Zhao +27 more
TL;DR: The hypothesis that alteration of gut microbiota may be involved in the alleviation of T2DM with hyperlipidemia by metformin and a specifically designed Chinese herbal formula (AMC) is tested and suggests that gut microbiota serves as a promising target for disease control.
Patent
Synergistic bacterial compositions and methods of production and use thereof
Matthew R. Henn,Geoffrey von Maltzahn,Anthony D'Onofrio,Kevin Litcofsky,David Arthur Berry,David N. Cook,Noubar B. Afeyan,John G. Aunins +7 more
TL;DR: In this paper, therapeutic compositions containing Ecobiotic populations for prevention, treatment and reduction of symptoms associated with dysbiosis of a mammalian subject such as a human were provided, and the compositions were evaluated.
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