Cell Biology of Astrocyte-Synapse Interactions
Nicola J. Allen,Cagla Eroglu +1 more
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TLDR
This review summarizes some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication and poses some pressing questions that need to be addressed to advance mechanistic understanding of the role ofAstrocytes in regulating synaptic development.About:
This article is published in Neuron.The article was published on 2017-11-01 and is currently open access. It has received 586 citations till now. The article focuses on the topics: Synapse & Astrocyte.read more
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Glia as architects of central nervous system formation and function
Nicola J. Allen,David A. Lyons +1 more
TL;DR: An overview of how the diverse and dynamic functions of glial cells orchestrate essentially all aspects of nervous system formation and function is provided.
Journal ArticleDOI
Identification of region-specific astrocyte subtypes at single cell resolution
Mykhailo Y. Batiuk,Araks Martirosyan,Jérôme Wahis,Filip De Vin,Catherine Marneffe,Carola Kusserow,Jordan Koeppen,João Filipe Viana,João Filipe Oliveira,João Filipe Oliveira,Thierry Voet,Thierry Voet,Chris P. Ponting,Chris P. Ponting,Chris P. Ponting,T. Grant Belgard,Matthew Holt,Matthew Holt +17 more
TL;DR: Using single cell transcriptome sequencing, the authors identify multiple astrocyte subtypes in the adult mouse CNS, which map to distinct spatial locations and show correlations to cell morphology and physiology.
Journal ArticleDOI
Astrocyte Crosstalk in CNS Inflammation.
TL;DR: In this paper, the authors provide an overview of the multifaceted roles of astrocytes in the context of CNS inflammation and neurodegeneration, and explore mechanisms of crosstalk between cells in the central nervous system (CNS) and discuss how these interactions shape pathological outcomes.
Journal ArticleDOI
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity.
TL;DR: This review discusses the goal of differentiating reactive astrocyte subtypes and states based on composite pictures of molecular expression, cell morphology, cellular interactions, proliferative state, normal functions, and disease-induced dysfunctions.
References
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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Ye Zhang,Kenian Chen,Steven A. Sloan,Mariko L. Bennett,Anja R. Scholze,Sean O'Keeffe,Hemali Phatnani,Paolo Guarnieri,Christine Caneda,Nadine Ruderisch,Shuyun Deng,Shane A. Liddelow,Chaolin Zhang,Richard Daneman,Tom Maniatis,Ben A. Barres,Jian Qian Wu +16 more
TL;DR: The authors' data provide clues as to how neurons and astrocytes differ in their ability to dynamically regulate glycolytic flux and lactate generation attributable to unique splicing of PKM2, the gene encoding the glycoleytic enzyme pyruvate kinase.
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Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
Dorothy P. Schafer,Emily K. Lehrman,Amanda G. Kautzman,Ryuta Koyama,Alan R. Mardinly,Ryo Yamasaki,Richard M. Ransohoff,Michael E. Greenberg,Ben A. Barres,Beth Stevens +9 more
TL;DR: It is shown that microglia engulf presynaptic inputs during peak retinogeniculate pruning and that engulfment is dependent upon neural activity and themicroglia-specific phagocytic signaling pathway, complement receptor 3(CR3)/C3.
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A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.
John D. Cahoy,Ben Emery,Amit Kaushal,Lynette C. Foo,Jennifer L. Zamanian,Karen S. Christopherson,Yi Xing,Jane L. Lubischer,Paul A. Krieg,Sergey A. Krupenko,Wesley J. Thompson,Ben A. Barres +11 more
TL;DR: These findings call into question the concept of a “glial” cell class as the gene profiles of astrocyte and oligodendrocytes are as dissimilar to each other as they are to neurons, for better understanding of neural development, function, and disease.
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Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Amit Zeisel,Ana B. Muñoz-Manchado,Simone Codeluppi,Peter Lönnerberg,Gioele La Manno,Anna Juréus,Sueli Marques,Hermany Munguba,Liqun He,Christer Betsholtz,Christer Betsholtz,Charlotte Rolny,Gonçalo Castelo-Branco,Jens Hjerling-Leffler,Sten Linnarsson +14 more
TL;DR: Large-scale single-cell RNA sequencing is used to classify cells in the mouse somatosensory cortex and hippocampal CA1 region and found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex.
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Tripartite synapses : Glia, the unacknowledged partner
TL;DR: It is suggested that perisynaptic Schwann cells and synaptically associated astrocytes should be viewed as integral modulatory elements of tripartite synapses.
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