Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Charissa Kim,Ruli Gao,Emi Sei,Rachel Brandt,Johan Hartman,Thomas Hatschek,Nicola Crosetto,Theodoros Foukakis,Nicholas Navin +8 more
TLDR
The data showed that resistant genotypes were pre-existing and adaptively selected by NAC, while transcriptional profiles were acquired by reprogramming in response to chemotherapy in TNBC patients.About:
This article is published in Cell.The article was published on 2018-05-03 and is currently open access. It has received 684 citations till now. The article focuses on the topics: Exome sequencing & Single cell sequencing.read more
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Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies
Joanna Cyrta,Davide Prandi,Arshi Arora,Daniel H. Hovelson,Andrea Sboner,Antonio Rodriguez,Tarcisio Fedrizzi,Himisha Beltran,Dan R. Robinson,A. Gopalan,Lawrence D. True,Peter S. Nelson,Brian D. Robinson,Juan Miguel Mosquera,Scott A. Tomlins,Ronglai Shen,Francesca Demichelis,Mark A. Rubin +17 more
TL;DR: The results emphasize pathologic and molecular heterogeneity of primary PCa, and suggest that comprehensive IHC‐assisted pathology review and genomic analysis are highly concordant in nominating the ‘index’ primary PCA area.
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OUP accepted manuscript
TL;DR: Wang et al. as discussed by the authors proposed single-cell consensus optimization of differentially expressed gene detection, an R package to automatically optimize DE gene detection for each experimental scRNA-seq dataset.
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Potential Mechanism Underlying the Role of Mitochondria in Breast Cancer Drug Resistance and Its Related Treatment Prospects.
Yuefeng Li,Zhian Li +1 more
TL;DR: In this article, the authors provide an overview of studies that investigated mitochondrial metabolism pathways in breast cancer treatment resistance, and discuss the application prospects of agents targeting mitochondrial pathways against drug-resistant breast cancer.
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Coriolic Acid (13-(S)-Hydroxy-9Z, 11E-octadecadienoic Acid) from Glasswort (Salicornia herbacea L.) Suppresses Breast Cancer Stem Cell through the Regulation of c-Myc.
TL;DR: Results indicated that coriolic acid could be a novel compound to target BCSCs via regulation of c-Myc, a cancer stem cell (CSC) phenotype, and specific genes related to CSCs, such as Nanog,Oct4, and CD44.
Journal ArticleDOI
Single-genome sequencing reveals within-host evolution of human malaria parasites.
Aliou Dia,Catherine Jett,Simon G. Trevino,Cindy S. Chu,Cindy S. Chu,Kanlaya Sriprawat,Tim J. Anderson,François Nosten,François Nosten,Ian H. Cheeseman +9 more
TL;DR: In this article, the authors used single-cell sequencing protocol for low-parasitaemia infections to generate 406 near-complete single Plasmodium vivax genomes from 11 patients sampled during sequential febrile episodes.
References
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The Sequence Alignment/Map format and SAMtools
Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
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TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
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TL;DR: The GATK programming framework enables developers and analysts to quickly and easily write efficient and robust NGS tools, many of which have already been incorporated into large-scale sequencing projects like the 1000 Genomes Project and The Cancer Genome Atlas.
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