Collagen Prolyl Hydroxylases are Essential for Breast Cancer Metastasis
Daniele M. Gilkes,Pallavi Chaturvedi,Saumendra Bajpai,Carmen Chak-Lui Wong,Hong Wei,Stephen Pitcairn,Maimon E. Hubbi,Denis Wirtz,Gregg L. Semenza +8 more
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TLDR
It is demonstrated that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells, resulting in enhanced invasion and metastasis to lymph nodes and lungs.Abstract:
The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis of human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells. We show that expression of collagen prolyl hydroxylases promotes cancer cell alignment along collagen fibers, resulting in enhanced invasion and metastasis to lymph nodes and lungs. Finally, we establish the prognostic significance of collagen prolyl hydroxylase mRNA expression in human breast cancer biopsies and show that ethyl 3,4-dihydroxybenzoate, a prolyl hydroxylase inhibitor, decreases tumor fibrosis and metastasis in a mouse model of breast cancer.read more
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Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma.
TL;DR: It is confirmed that P4HA1 is a promising biomarker of poor prognosis and relates to immune infiltrates in LUAD.
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Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy
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Dissertation
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation across gestation
Anti-oxidant and Anti-aging Effect of Extracts from Seed of Camellia japonica L. by Supercritical Fluid Extraction
TL;DR: In this paper, the anti-oxidant and anti-aging effect of Camellia japonica L. extracted by supercritical CO2 was investigated and the results showed that oleic acid was 84% and the antioxidant effect was about 186% compared with alpha-tocoperol(0.1%) by beta carotene bleaching assay.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
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Peter Friedl,Katarina Wolf +1 more
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