Collagen Prolyl Hydroxylases are Essential for Breast Cancer Metastasis
Daniele M. Gilkes,Pallavi Chaturvedi,Saumendra Bajpai,Carmen Chak-Lui Wong,Hong Wei,Stephen Pitcairn,Maimon E. Hubbi,Denis Wirtz,Gregg L. Semenza +8 more
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TLDR
It is demonstrated that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells, resulting in enhanced invasion and metastasis to lymph nodes and lungs.Abstract:
The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis of human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells. We show that expression of collagen prolyl hydroxylases promotes cancer cell alignment along collagen fibers, resulting in enhanced invasion and metastasis to lymph nodes and lungs. Finally, we establish the prognostic significance of collagen prolyl hydroxylase mRNA expression in human breast cancer biopsies and show that ethyl 3,4-dihydroxybenzoate, a prolyl hydroxylase inhibitor, decreases tumor fibrosis and metastasis in a mouse model of breast cancer.read more
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Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Michael S. Toss,Michael S. Toss,Islam M. Miligy,Islam M. Miligy,Kylie L. Gorringe,Kylie L. Gorringe,Luke McCaffrey,Abdulbaqi AlKawaz,Abdulbaqi AlKawaz,Asima Abidi,Ian O. Ellis,Andrew R. Green,Emad A. Rakha,Emad A. Rakha +13 more
TL;DR: High legumain expression is associated with poor prognosis in DCIS and could be a potential marker to predict DCIS progression to invasive disease.
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Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry
Peggi M. Angel,Laura Spruill,Melanie Jefferson,Jennifer R. Bethard,Lauren E. Ball,Chanita Hughes-Halbert,Richard R. Drake +6 more
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The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer.
Hannah E. Majeski,Jing Yang +1 more
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A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor β1
TL;DR: The findings reveal the existence of a hierarchical relationship between the HIF and SMAD signaling pathways for hypoxia– and TGF-β1–mediated regulation of PLOD2 expression, a key event in the deposition of collagen into the ECM.
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Prolyl 4-hydroxylase subunit alpha 3 presents a cancer promotive function in head and neck squamous cell carcinoma via regulating epithelial-mesenchymal transition.
TL;DR: It is deduced that P4HA3 acts as an oncogene that raises tumor cell viability and metastasis partly by inducing the epithelial-mesenchymal transition process, suggesting that P 4HA3 may be considered as a valuable biomarker for head and neck squamous cell carcinoma treatment.
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TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental,Hongmei Yu,Laura Kass,Johnathon N. Lakins,Mikala Egeblad,Janine T. Erler,Sheri F. T. Fong,Katalin Csiszar,Amato J. Giaccia,Wolfgang Weninger,Mitsuo Yamauchi,David L. Gasser,Valerie M. Weaver +12 more
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