Directed Differentiation of Embryonic Stem Cells into Motor Neurons
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It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.About:
This article is published in Cell.The article was published on 2002-08-09 and is currently open access. It has received 1763 citations till now. The article focuses on the topics: Motor neuron & Neurogenesis.read more
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Stem cells and neurodegenerative diseases
LingLing Hou,Tao Hong +1 more
TL;DR: The progress and prospects of various stem cells, including embryonic stem cell, mesenchymal stem cell and neural stem cells and so on, for the treatments of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer's disease, Huntington’ disease and Amyotrophic lateral sclerosis/Lou Gehrig's disease are reviewed.
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Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane
Huateng Zhou,Wang Lixiang,Cui Zhang,Jintao Hu,Jianlin Chen,Du Weibin,Fei Liu,Weifan Ren,Jinfu Wang,Renfu Quan +9 more
TL;DR: Results indicated that transplantation of a hAAM combined with iPS-derived EpSCs is feasible to reconstruct skin and skin appendages, and may be a substantial reference for iPSC-based therapy for skin defects.
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Spinal muscular atrophy: Advances in research and consensus on care of patients
Ching H Wang,Mitchell R. Lunn +1 more
TL;DR: Three groups of compounds have been identified as therapeutic candidates for SMA, and one group was identified before the molecular genetics of SMA was understood, chosen on the basis of their effectiveness in similar neurologic disorders.
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Compartmental culture of embryonic stem cell-derived neurons in microfluidic devices for use in axonal biology
TL;DR: In this research, ESC_Ns were derived from mouse ESCs in compartmental microfluidic devices, and their axons were isolated from the somal cell bodies, providing an arrangement comparable to dissociated primary neurons.
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miRNA let-7e Modulates the Wnt Pathway and Early Nephrogenic Markers in Mouse Embryonic Stem Cell Differentiation
Jose Luis Viñas,Marina Ventayol,Bernhard Brüne,Michaela Jung,Anna M. Solà,Felip Pi,Chrysoula Mastora,Chrysoula Mastora,Georgina Hotter +8 more
TL;DR: It is indicated that embryonic stem cells cultured with retinoic acid and activin A significantly upregulate the miRNA let-7e, which modulates the Wnt pathway and the expression of early nephrogenic markers under these differentiation conditions.
References
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Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chin Chiang,Ying Litingtung,Eric Lee,Keith E. Young,Jeffrey L Corden,Heiner Westphal,Philip A. Beachy +6 more
TL;DR: Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs.
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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Naohiro Terada,Takashi Hamazaki,Masahiro Oka,Masanori Hoki,Diana M. Mastalerz,Yuka Nakano,Edwin M. Meyer,Laurence Morel,Bryon E. Petersen,Edward W. Scott +9 more
TL;DR: It is demonstrated that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3, which, without detailed genetic analysis, might be interpreted as ‘dedifferentiation’ or transdifferentiation.
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Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
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In vitro differentiation of transplantable neural precursors from human embryonic stem cells
TL;DR: In vitro differentiation, enrichment, and transplantation of neural precursor cells from human ES cells are described, depicting humanES cells as a source of transplantable neural precursors for possible nervous system repair.