Directed Differentiation of Embryonic Stem Cells into Motor Neurons
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It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.About:
This article is published in Cell.The article was published on 2002-08-09 and is currently open access. It has received 1763 citations till now. The article focuses on the topics: Motor neuron & Neurogenesis.read more
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Embryonic wound healing: A primer for engineering novel therapies for tissue repair
TL;DR: This review provides a comparative overview of wound healing during development and maturation and seeks to provide a perspective on just how much the embryo may be able to teach us in the engineering of new therapies for tissue repair.
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Effect of leukemia inhibitory factor on embryonic stem cell differentiation: implications for supporting neuronal differentiation
TL;DR: It is suggested that LIF plays a positive role during the differentiation of ES cells into neuronal cells, and suppressed cell apoptosis and promoted cell proliferation during ES cell differentiation.
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Erratum to: Differentiation Potential of Human Chorion-Derived Mesenchymal Stem Cells into Motor Neuron-Like Cells in Two- and Three-Dimensional Culture Systems.
Faezeh Faghihi,Esmaeil Mirzaei,Jafar Ai,Abolfazl Lotfi,Forough Azam Sayahpour,Somayeh Ebrahimi-Barough,Mohammad Taghi Joghataei +6 more
TL;DR: The effect of retinoic acid (RA) and sonic hedgehog (Shh) on differentiation of human C-MSCs into motor neuron-like cells cultured on tissue culture plates and electrospun nanofibrous gelatin scaffold (3D) is determined.
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Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors
Marco Terenzio,Matthew Golding,Matthew R. G. Russell,Krzysztof B. Wicher,Ian Rosewell,Bradley Spencer-Dene,David Ish-Horowicz,Giampietro Schiavo,Giampietro Schiavo +8 more
TL;DR: Depleting BICD1 increased the intracellular accumulation of brain‐derived neurotrophic factor (BDNF)‐activated TrkB and p75 neurotrophin receptor (p75NTR) by disrupting the endosomal sorting of internalised ligand‐activated receptors, and resulted in attenuated, but more sustained, AKT activation in response to BDNF stimulation.
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Core promoter factor TAF9B regulates neuronal gene expression.
TL;DR: It is reported that the orphan TBP-associated factor TAF9B is selectively up-regulated upon in vitro motor neuron differentiation, and is required for the transcriptional induction of specific neuronal genes, while dispensable for global gene expression in murine ES cells.
References
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Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chin Chiang,Ying Litingtung,Eric Lee,Keith E. Young,Jeffrey L Corden,Heiner Westphal,Philip A. Beachy +6 more
TL;DR: Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs.
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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Naohiro Terada,Takashi Hamazaki,Masahiro Oka,Masanori Hoki,Diana M. Mastalerz,Yuka Nakano,Edwin M. Meyer,Laurence Morel,Bryon E. Petersen,Edward W. Scott +9 more
TL;DR: It is demonstrated that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3, which, without detailed genetic analysis, might be interpreted as ‘dedifferentiation’ or transdifferentiation.
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Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
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In vitro differentiation of transplantable neural precursors from human embryonic stem cells
TL;DR: In vitro differentiation, enrichment, and transplantation of neural precursor cells from human ES cells are described, depicting humanES cells as a source of transplantable neural precursors for possible nervous system repair.