Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
David Chien,A. Katrin Szardenings,Shadfar Bahri,Joseph C. Walsh,Fanrong Mu,Chunfang Xia,William R. Shankle,Alan J. Lerner,Min-Ying Su,Arkadij M. Elizarov,Hartmuth C. Kolb +10 more
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TLDR
First human brain images with [F18]-T808, a novel PHF-tau targeting PET imaging agent with different pharmacokinetic characteristics, are described, which may be favorable for imaging Alzheimer's disease and other tauopathies.Abstract:
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.read more
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Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia.
Young Kyoung Jang,Chul Hyoung Lyoo,Seongbeom Park,Seung Jun Oh,Hanna Cho,Minyoung Oh,Young Hoon Ryu,Jae Yong Choi,Gil D. Rabinovici,Gil D. Rabinovici,Hee Jin Kim,Seung Hwan Moon,Hyemin Jang,Jin San Lee,William J. Jagust,William J. Jagust,Duk L. Na,Duk L. Na,Jae Seung Kim,Sang Won Seo +19 more
TL;DR: AV-1451 is more sensitive and specific to Alzheimer’s disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.
Journal ArticleDOI
In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510.
Ai Ishikawa,Masaki Tokunaga,Jun Maeda,Takeharu Minamihisamatsu,Masafumi Shimojo,Hiroyuki Takuwa,Maiko Ono,Ruiqing Ni,Shigeki Hirano,Satoshi Kuwabara,Bin Ji,Ming-Rong Zhang,Ichio Aoki,Tetsuya Suhara,Makoto Higuchi,Naruhiko Sahara +15 more
TL;DR: The time-course of the [11C]PBB3- and TSPO-PET finding suggests that tau deposition triggers progressive neuroinflammation, and the sequential changes can be evaluated in vivo in mouse brains.
Monitoring and Assessment Technologies Cognitive changes and dementia risk after traumatic brain injury: Implications for aging military personnel *
TL;DR: In this article, the authors reviewed the neurocognitive and neuropathologic changes after Traumatic Brain Injury (TBI) with a focus on the potential risk for cognitive and neurological changes after TBI.
Journal ArticleDOI
PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies.
Stephen N. Gomperts,Marta Marquié,Joseph J. Locascio,Stephen Bayer,Keith A. Johnson,John H. Growdon +5 more
TL;DR: DAT and amyloid PET imaging discriminate DLB from PD and from other disease groups and identify pathological processes that contribute to their course and serve as biomarkers for targeted molecular therapies.
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Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau.
TL;DR: Evidence suggesting that tau may exhibit properties similar to those of prions, although infective transmission has not been shown, has been shown in a few clinical trials targeting tau and microtubule dysfunction, although none have had any disease‐modifying effects.
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