Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
David Chien,A. Katrin Szardenings,Shadfar Bahri,Joseph C. Walsh,Fanrong Mu,Chunfang Xia,William R. Shankle,Alan J. Lerner,Min-Ying Su,Arkadij M. Elizarov,Hartmuth C. Kolb +10 more
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TLDR
First human brain images with [F18]-T808, a novel PHF-tau targeting PET imaging agent with different pharmacokinetic characteristics, are described, which may be favorable for imaging Alzheimer's disease and other tauopathies.Abstract:
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.read more
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Tau and neurodegenerative disease: the story so far
TL;DR: An overview of the pivotal discoveries in the tau research field over the past 40 years is provided, including disease mechanisms and therapeutic approaches, and the current status of the field is reviewed.
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The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
TL;DR: Recent progress in cognitive, imaging, and biomarker outcomes in the field of preclinical Alzheimer's disease, and the remaining gaps in knowledge are highlighted.
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William E. Klunk,William E. Klunk,Robert A. Koeppe,Julie C. Price,Tammie L.S. Benzinger,Tammie L.S. Benzinger,Michael D. Devous,William J. Jagust,Keith A. Johnson,Chester A. Mathis,Davneet S. Minhas,Michael J. Pontecorvo,Christopher C. Rowe,Daniel Skovronsky,Mark A. Mintun +14 more
TL;DR: A working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls and typical Alzheimer's disease patients.
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Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease
Matthew R. Brier,Brian A. Gordon,Karl A. Friedrichsen,John E. McCarthy,Ari Stern,Jon Christensen,Christopher J. Owen,Patricia Aldea,Yi Su,Jason Hassenstab,Nigel J. Cairns,David M. Holtzman,Anne M. Fagan,John C. Morris,Tammie L.S. Benzinger,Beau M. Ances +15 more
TL;DR: Tau deposition in the temporal lobe more closely tracked dementia status and was a better predictor of cognitive performance than Aβ deposition in any region of the brain, supporting models of AD where tau pathology closely tracks changes in brain function that are responsible for the onset of early symptoms in AD.
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PROTAC targeted protein degraders: the past is prologue
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