Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
David Chien,A. Katrin Szardenings,Shadfar Bahri,Joseph C. Walsh,Fanrong Mu,Chunfang Xia,William R. Shankle,Alan J. Lerner,Min-Ying Su,Arkadij M. Elizarov,Hartmuth C. Kolb +10 more
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TLDR
First human brain images with [F18]-T808, a novel PHF-tau targeting PET imaging agent with different pharmacokinetic characteristics, are described, which may be favorable for imaging Alzheimer's disease and other tauopathies.Abstract:
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.read more
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Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease.
Catherine M. Roe,Ganesh M. Babulal,Shruti Mishra,Brian A. Gordon,Sarah H. Stout,Brian R. Ott,David B. Carr,Beau M. Ances,John C. Morris,Tammie L.S. Benzinger +9 more
TL;DR: Participants at Stage 2 (positive amyloid and tau scans) of preclinical AD were more likely to receive a marginal/fail rating compared to participants at Stage 0 or 1, which may manifest in worse driving performance.
Journal ArticleDOI
PET Radioligands for Imaging of Tau Pathology: Current Status
TL;DR: This review focuses on lead radioligands developed to date and their preclinical data in order to facilitate the development of tau-specific positron emission tomography radiolIGands that are of great interest to the scientific community.
Posted ContentDOI
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
William Richard Bevan-Jones,Thomas E. Cope,P.S. Jones,Luca Passamonti,Young T. Hong,Tim D. Fryer,Robert Arnold,Jonathan P. Coles,Franklin I. Aigbirhio,Andrew J Larner,Karalyn Patterson,John T. O'Brien,James B. Rowe +12 more
TL;DR: In vivo findings indicate a close association between neuroinflammation and protein aggregation in frontotemporal dementia and the inflammatory component may be important in shaping the clinical and neuropathological patterns of the diverse clinical syndromes of frontotmporal dementia.
Posted ContentDOI
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease
Edmarie Guzmán-Vélez,Ibai Diez,Dorothee Schoemaker,Enmanuelle Pardilla-Delgado,Clara Vila-Castelar,Joshua T Fox-Fuller,Ana Baena,Reisa A. Sperling,Keith A. Johnson,Francisco Lopera,Jorge Sepulcre,Yakeel T. Quiroz +11 more
TL;DR: In this paper, high-resolution graph-based network analyses were used to test whether in vivo amyloid-{beta} and tau burden related to segregation and integration of functional brain connections, and their association with memory, in cognitively-unimpaired Presenilin-1 E280A carriers who will develop early-onset AD dementia.
Book ChapterDOI
Tau PET Imaging.
TL;DR: A novel radiocompound developed by the research group has been shown to produce high contrasts for AD and non-AD tau aggregates, potentially allowing diagnostic evaluations of diverse tauopathies on an individual basis.
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