Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
David Chien,A. Katrin Szardenings,Shadfar Bahri,Joseph C. Walsh,Fanrong Mu,Chunfang Xia,William R. Shankle,Alan J. Lerner,Min-Ying Su,Arkadij M. Elizarov,Hartmuth C. Kolb +10 more
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TLDR
First human brain images with [F18]-T808, a novel PHF-tau targeting PET imaging agent with different pharmacokinetic characteristics, are described, which may be favorable for imaging Alzheimer's disease and other tauopathies.Abstract:
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.read more
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