Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.
Marcel Martin,Marcel Martin,Lars Maßhöfer,Petra Temming,Sven Rahmann,Claudia H D Metz,Norbert Bornfeld,Johannes van de Nes,Ludger Klein-Hitpass,Alan G. Hinnebusch,Bernhard Horsthemke,Dietmar R. Lohmann,Michael Zeschnigk +12 more
TLDR
Using exome sequencing, recurrent somatic mutations in EIF1AX and SF3B1 are identified occurring in uveal melanomas with disomy 3, which rarely metastasize and are associated with poor prognosis.Abstract:
Michael Zeschnigk and colleagues identify recurrent somatic mutations of EIF1AX and SF3B1 in uveal melanomas with disomy 3. The EIF1AX mutations specifically alter the N-terminal tail of the protein and were found exclusively in tumors lacking SF3B1 mutations.read more
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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
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TL;DR: The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class.
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Integrated Genomic Characterization of Papillary Thyroid Carcinoma
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A. Hunter Shain,Iwei Yeh,Ivanka Kovalyshyn,Aravindhan Sriharan,Eric Talevich,Alexander Gagnon,Reinhard Dummer,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,William Rickaby,Corrado D’Arrigo,Alistair Robson,Boris C. Bastian +13 more
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Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
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TL;DR: These data support a model of tumorigenesis whereby PDTCs and ATCs arise from well-differentiated tumors through the accumulation of key additional genetic abnormalities, many of which have prognostic and possible therapeutic relevance.
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RNA in cancer.
TL;DR: The regulation of gene expression by coding and non-coding RNA is introduced and both established and emerging roles for RNAs in cancer are discussed, highlighting the potential mechanisms by which these RNA subtypes contribute to cancer.
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