Journal ArticleDOI
Exosome mediated communication within the tumor microenvironment.
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TLDR
The aberrant exosomal process in cancer is conceptualized as being partially attributed to cancer specific differences in the endocytotic process of receptor recycling/degradation and plasma membrane remodeling and the function of the endosome as a signaling entity.About:
This article is published in Journal of Controlled Release.The article was published on 2015-12-10. It has received 534 citations till now. The article focuses on the topics: Exosome & Cancer.read more
Citations
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Role of exosomes in pancreatic cancer
TL;DR: The present review discusses the interactions between exosomes and the pathophysiology of PC, and the potential clinical applications of exosome.
Journal ArticleDOI
Developments in predictive biomarkers for hepatocellular carcinoma therapy.
TL;DR: It is thought that combining multi-OMICS with radiomics represents apromising strategy for evaluating tumor heterogenicity and for identifying biomarkers of response and prognosis.
Journal ArticleDOI
Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)
TL;DR: Taken together, exosomal miRNAs and proteins may be used as noninvasive, novel biomarkers for cancer diagnosis, prognosis or precision treatment owing to their able to promote tumor progression and metastasis, and their ability to regulate the immune response and tumor cell sensitivity to chemotherapy drugs.
Journal ArticleDOI
Tumor-Derived Extracellular Vesicles Regulate Cancer Progression in the Tumor Microenvironment
TL;DR: This article focuses on presenting a comprehensive and critical overview of the potential role of tumor-derived EVs-mediated communication in the tumor microenvironment.
Journal ArticleDOI
Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma
Vincent Yeung,Jason P. Webber,Elaine A. Dunlop,Huw Morgan,Joseph Hutton,Mark Gurney,E Jones,Juan M. Falcón-Pérez,Zsuzsanna Tabi,Rachel J. Errington,Aled Clayton +10 more
TL;DR: The study concludes that a RAB35 regulated nanovesicle sub-population is particularly important for communication between cancer and stromal cells, and is required for generating a tumour-supportive microenvironment.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Johan Skog,T. Wurdinger,van Rijn S,Dimphna H. Meijer,Gainche L,Miguel Sena-Esteves,William T. Curry,Bob S. Carter,Anna M. Krichevsky,Xandra O. Breakefield +9 more
TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.
Journal ArticleDOI
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
Journal ArticleDOI
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
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