Journal ArticleDOI
Exosome mediated communication within the tumor microenvironment.
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TLDR
The aberrant exosomal process in cancer is conceptualized as being partially attributed to cancer specific differences in the endocytotic process of receptor recycling/degradation and plasma membrane remodeling and the function of the endosome as a signaling entity.About:
This article is published in Journal of Controlled Release.The article was published on 2015-12-10. It has received 534 citations till now. The article focuses on the topics: Exosome & Cancer.read more
Citations
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The CD8⁺ T Cell-Mediated Immunity Induced by HPV-E6 Uploaded in Engineered Exosomes Is Improved by ISCOMATRIX(TM) Adjuvant.
Francesco Manfredi,Paola Di Bonito,Barbara Ridolfi,Simona Anticoli,Claudia Arenaccio,Chiara Chiozzini,Adriana Baz Morelli,Maurizio Federico +7 more
TL;DR: It is found that the in vitro co-administration of engineered exosomes and ISCOMATRIXTM adjuvant led to a stronger antigen cross-presentation in both B- lymphoblastoid cell lines and monocyte-derived immature dendritic cells compared with that induced by the exosome alone.
Journal ArticleDOI
Current Understanding of Exosomal MicroRNAs in Glioma Immune Regulation and Therapeutic Responses
Jinwu Peng,Qiuju Liang,Zhijie Xu,Yuan Cai,Bi Peng,Jianbo Li,Wenqin Zhang,Fanhua Kang,Qi-Sheng Hong,Yuanliang Yan,Mingyu Zhang +10 more
TL;DR: The novel findings regarding the biological functions of exosomal miRNAs during glioma pathogenesis and immune regulation are reviewed and their potential clinical applications as biomarkers in gliomas diagnosis, prognosis and treatment response prediction are elaborated.
Journal ArticleDOI
Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction.
Franziska Böttger,Tieneke B M Schaaij-Visser,Inge de Reus,Sander R. Piersma,Thang V. Pham,Remco Nagel,Ruud H. Brakenhoff,Erik Thunnissen,Egbert F. Smit,Connie R. Jimenez +9 more
TL;DR: Proteome profiling of the conditioned media (secretomes) of a panel of NSCLC cell lines in relation to cisplatin IC50 values is reported, revealing biofluid biomarker candidates that, with further validation, may be used for non-invasive cisPlatin response prediction in the future.
Journal ArticleDOI
A multi-parallel N-glycopeptide enrichment strategy for high-throughput and in-depth mapping of the N-glycoproteome in metastatic human hepatocellular carcinoma cell lines.
Biyun Jiang,Jiangming Huang,Zixiang Yu,Mengxi Wu,Mingqi Liu,Jun Yao,Huanhuan Zhao,Guoquan Yan,Wantao Ying,Weiqian Cao,Pengyuan Yang +10 more
TL;DR: The in-depth glycoproteome mapping provides insight into the N-glycosylation status in HCC cell lines with differences in metastatic potential and contributes to biomarker discovery.
Journal ArticleDOI
Microfluidic systems for the analysis of blood‐derived molecular biomarkers
Oriana Gerallin Chavez-Pineda,Roberto Rodriguez-Moncayo,Diana F. Cedillo-Alcantar,Pablo E Guevara-Pantoja,Josue U. Amador-Hernandez,Jose L. Garcia-Cordero +5 more
TL;DR: A review of the microfluidic systems that have been engineered to detect circulating molecular biomarkers in blood plasma and the different microfluidity approaches for plasma enrichment, which are now being integrated with microfluideic‐based biomarker analyzers, with special relevance to POC platforms.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Johan Skog,T. Wurdinger,van Rijn S,Dimphna H. Meijer,Gainche L,Miguel Sena-Esteves,William T. Curry,Bob S. Carter,Anna M. Krichevsky,Xandra O. Breakefield +9 more
TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.
Journal ArticleDOI
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
Journal ArticleDOI
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
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