Journal ArticleDOI
Exosome mediated communication within the tumor microenvironment.
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TLDR
The aberrant exosomal process in cancer is conceptualized as being partially attributed to cancer specific differences in the endocytotic process of receptor recycling/degradation and plasma membrane remodeling and the function of the endosome as a signaling entity.About:
This article is published in Journal of Controlled Release.The article was published on 2015-12-10. It has received 534 citations till now. The article focuses on the topics: Exosome & Cancer.read more
Citations
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Journal ArticleDOI
Progress in Exosome Isolation Techniques.
TL;DR: An overview of exosome isolation techniques is provided, opening up new perspectives towards the development more innovative strategies and devices for more time saving, cost effective, and efficient isolations ofExosomes from a wide range of biological matrices.
Journal ArticleDOI
Engineering exosomes as refined biological nanoplatforms for drug delivery.
TL;DR: Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved in a diverse range of biological processes as mentioned in this paper.
Journal ArticleDOI
Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer.
Tian Fang,Hongwei Lv,Guishuai Lv,Ting Li,Changzheng Wang,Qin Han,Le-Xing Yu,Bo Su,Lin-Na Guo,Shanna Huang,Dan Cao,Liang Tang,Shanhua Tang,Meng-Chao Wu,Wen Yang,Hongyang Wang,Hongyang Wang +16 more
TL;DR: In a lung metastatic niche, high-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that leads to activation of β1-integrin-NF-κBsignalling, converting fibroblasts to cancer-associated fibro Blasts, providing potential targets for prevention and treatment of cancer metastasis.
Journal ArticleDOI
Exosomes and Ectosomes in Intercellular Communication
TL;DR: Exosomes and ectosomes, two distinct types of extracellular vesicles generated by all types of cell, play key roles in intercellular communication and are useful in the development of innovative therapeutic approaches.
Journal ArticleDOI
Exosomes: key players in cancer and potential therapeutic strategy.
Jie Dai,Yangzhou Su,Suye Zhong,Li Cong,Bang Liu,Junjun Yang,Yongguang Tao,Zuping He,Chao Chen,Yiqun Jiang +9 more
TL;DR: The role of exosome contents in cancer, focusing on proteins and noncoding RNA; the interaction between exosomes and tumor microenvironment; the mechanisms that epithelial-mesenchymal transition, invasion and migration of tumor affected by exosomers; and tumor suppression strategies based on exosomal components are summarized.
References
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Journal ArticleDOI
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.
Joseph Wolfers,A. Lozier,Graça Raposo,Armelle Regnault,Clotilde Théry,Carole Masurier,Caroline Flament,Stéphanie Pouzieux,Florence Faure,Thomas Tursz,Eric Angevin,Sebastian Amigorena,Laurence Zitvogel +12 more
TL;DR: It is shown in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells, relevant for immunointerventions.
Journal ArticleDOI
Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles
Clotilde Théry,Muriel Boussac,Philippe Veron,Paola Ricciardi-Castagnoli,Graça Raposo,Jérôme Garin,Sebastian Amigorena +6 more
TL;DR: Using a systematic proteomic approach, the first extensive protein map of a particular exosome population is established and a novel category of exosomal proteins related to apoptosis is identified: thioredoxin peroxidase II, Alix, 14-3-3, and galectin-3.
Journal ArticleDOI
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
Ingo K. Mellinghoff,Maria Y. Wang,Igor Vivanco,Daphne A. Haas-Kogan,Shaojun Zhu,Ederlyn Q. Dia,Kan V. Lu,Koji Yoshimoto,Julie H. Y Huang,Dennis J. Chute,Bridget L. Riggs,Steve Horvath,Linda M. Liau,Webster K. Cavenee,P. Nagesh Rao,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Timothy C. Peck,Timothy C. Peck,Timothy C. Peck,Jeffrey C. Lee,Jeffrey C. Lee,Jeffrey C. Lee,William R. Sellers,William R. Sellers,William R. Sellers,David Stokoe,Michael D. Prados,Timothy F. Cloughesy,Charles L. Sawyers,Paul S. Mischel +31 more
TL;DR: Coexpression of EGFRvIII and PTEN by glioblastoma cells is associated with responsiveness to EGFR kinase inhibitors, and effects of the molecular abnormalities in vitro are identified.
Journal ArticleDOI
Biogenesis and secretion of exosomes
TL;DR: Interest in the release of membrane-enclosed vesicles by cells into their surrounding environment has been the subject of increasing interest in the past few years, and different families of molecules have been shown to allow intracellular formation of exosomes and their subsequent secretion, which suggests that even among exosome different sub-types exist.
Journal ArticleDOI
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Sonia A. Melo,Hikaru Sugimoto,Hikaru Sugimoto,Joyce T. O’Connell,Noritoshi Kato,Alberto Villanueva,August Vidal,Le Qiu,Edward Vitkin,Lev T. Perelman,Carlos A. Melo,Anthony Lucci,Cristina Ivan,George A. Calin,Raghu Kalluri,Raghu Kalluri +15 more
TL;DR: It is reported that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capacity to process precursor micro RNAs (pre-miRNas) into mature miRNAs.
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