Journal ArticleDOI
Exosome mediated communication within the tumor microenvironment.
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TLDR
The aberrant exosomal process in cancer is conceptualized as being partially attributed to cancer specific differences in the endocytotic process of receptor recycling/degradation and plasma membrane remodeling and the function of the endosome as a signaling entity.About:
This article is published in Journal of Controlled Release.The article was published on 2015-12-10. It has received 534 citations till now. The article focuses on the topics: Exosome & Cancer.read more
Citations
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Role of circular RNAs and long non‑coding RNAs in the clinical translation of gastric cancer (Review)
TL;DR: The present review focuses on the clinical translation of circRNAs and lncRNAs into GC and proposes serviceable suggestions for further development.
Journal ArticleDOI
Comparison of plasma- and saliva-derived exosomal miRNA profiles reveals diagnostic potential in head and neck cancer
Linda Hofmann,Tsima Abou Kors,J Ezic,Beate Niesler,Ralph Röth,Sonja Ludwig,Simon Laban,Patrick J. Schuler,Thomas K. Hoffmann,Cornelia Brunner,Valentin Medyany,Marie-Nicole Theodoraki +11 more
TL;DR: A plasma- and a saliva-derived panel of tumor-exclusive exosomal miRNAs hold great potential as liquid biopsy for discrimination between cancer and healthy as well as HPV status and disease stage.
Journal ArticleDOI
Exosomes: Ideal Diagnostic Biomarkers and Therapeutic Nanodevices of Pancreatic Cancer
Hongpei Wu,Bojun Bao,Hui Cong,Jinxia Liu,Jiang Feng,Wenkai Ni,Lishuai Qu,Cuihua Lu,Ni Runzhou,Xiao Mingbing +9 more
TL;DR: The function of exosomes, mainly in pancreatic cancer (proliferation, metastasis, drug resistance and immune reaction in tumor microenvironment), and importantly, the potential functions ofExosomes are summarized and the current challenges which may obstruct the clinical application are discussed.
Journal ArticleDOI
Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
TL;DR: Recent findings on the fundamental roles of exosomal ncRNAs in angiogenesis, vascular permeability, tumor immunity, tumor metabolism and drug resistance are summarized.
Journal ArticleDOI
Effect of modified Jianpi Yangzheng on regulating content of PKM2 in gastric cancer cells-derived exosomes.
Jian Wu,Mengyun Yuan,Junyu Shen,Yuxuan Chen,Ruijuan Zhang,Xu Chen,Haidan Wang,Zhonghua Yin,Xingxing Zhang,Shenlin Liu,Qingmin Sun +10 more
TL;DR: Wang et al. as mentioned in this paper investigated the potential role of gastric cancer exosomes containing pyruvate kinase M2 in regulating tumor-associated macrophages (TAM) and the mechanism of modified Jianpi Yangzheng decoction (mJPYZ).
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Johan Skog,T. Wurdinger,van Rijn S,Dimphna H. Meijer,Gainche L,Miguel Sena-Esteves,William T. Curry,Bob S. Carter,Anna M. Krichevsky,Xandra O. Breakefield +9 more
TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.
Journal ArticleDOI
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
Journal ArticleDOI
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
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