Journal ArticleDOI
Exosome mediated communication within the tumor microenvironment.
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TLDR
The aberrant exosomal process in cancer is conceptualized as being partially attributed to cancer specific differences in the endocytotic process of receptor recycling/degradation and plasma membrane remodeling and the function of the endosome as a signaling entity.About:
This article is published in Journal of Controlled Release.The article was published on 2015-12-10. It has received 534 citations till now. The article focuses on the topics: Exosome & Cancer.read more
Citations
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Exosomes as Carriers for Drug Delivery in Cancer Therapy
TL;DR: The composition, function, isolation and characterization ofExosomes are introduced, and the selection of exosome donor cells and methods for drug loading are described, and a comparison of the advantages and disadvantages of drug-loaded exosomes have been analyzed.
Journal ArticleDOI
Diagnostic performance of various liquid biopsy methods in detecting colorectal cancer: A meta‐analysis
Yuzhou Zhu,Tinghan Yang,Qingbin Wu,Xuyang Yang,Jianqi Hao,Xiangbing Deng,Shuo Yang,Chaoyang Gu,Ziqiang Wang +8 more
TL;DR: The overall performance of all liquid biopsy methods had great diagnostic value in detecting CRC, regardless of subtypes, and among all liquidBiopsy methods, CTCs showed the best diagnostic performance.
Journal ArticleDOI
Role of exosomes in tumour growth, chemoresistance and immunity: state-of-the-art
Seyedeh Maryam Hosseinikhah,Fatemeh Gheybi,Seyedeh Alia Moosavian,Mohammad-Ali Shahbazi,Mahmoud Reza Jaafari,Mika Sillanpää,Prashant Kesharwani,Seyedeh Hoda Alavizadeh,Amirhossein Sahebkar +8 more
TL;DR: The important role of tumor-derived exosomes in dictating cancer pathogenesis and resistance to therapy is summarized and the potential utility and significance of tumor exosome-based nanoparticles as an efficient and novel therapeutic carrier and their applications in treating advanced cancers are implicated.
Journal ArticleDOI
Current Perspectives on the Unique Roles of Exosomes in Drug Resistance of Hepatocellular Carcinoma
TL;DR: In this article , the authors discuss the underlying relationship between exosomes and drug resistance in hepatocellular carcinoma (HCC) and also show that exosome may act as candidate biomarkers for predicting and monitoring drug responses and as potential targets or vectors to reverse the drug resistance of HCC.
Journal ArticleDOI
The multifaceted involvement of exosomes in tumor progression: Induction and inhibition
Wen-Jie Gu,Yi-Wen Shen,Li-Jun Zhang,Hong Zhang,Dale G. Nagle,Dale G. Nagle,Xin Luan,Sanhong Liu +7 more
TL;DR: This review mainly introduces the versatile roles of tumor or stromal cell derived exosomes in cancer development, with a particular focus on the biological capabilities and functionalities of their diverse contents, such as miRNAs, lnc RNAs, and circRNAs.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Johan Skog,T. Wurdinger,van Rijn S,Dimphna H. Meijer,Gainche L,Miguel Sena-Esteves,William T. Curry,Bob S. Carter,Anna M. Krichevsky,Xandra O. Breakefield +9 more
TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.
Journal ArticleDOI
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
Journal ArticleDOI
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
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