Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Alison P. Klein,Brian M. Wolpin,Harvey A. Risch,Rachael Z. Stolzenberg-Solomon,Evelina Mocci,Mingfeng Zhang,Federico Canzian,Erica J. Childs,Jason W. Hoskins,Ashley Jermusyk,Jun Zhong,Fei Chen,Demetrius Albanes,Gabriella Andreotti,Alan A. Arslan,Ana Babic,William R. Bamlet,Laura Beane-Freeman,Sonja I. Berndt,Amanda L. Blackford,Michael Borges,Ayelet Borgida,Paige M. Bracci,Lauren K. Brais,Paul Brennan,Hermann Brenner,Bas Bueno-de-Mesquita,Julie E. Buring,Daniele Campa,Gabriele Capurso,Giulia Martina Cavestro,Kari G. Chaffee,Charles C. Chung,Charles C. Chung,Sean P. Cleary,Michelle Cotterchio,Frederike Dijk,Eric J. Duell,Lenka Foretova,Charles S. Fuchs,Niccola Funel,Steven Gallinger,J. Michael Gaziano,J. Michael Gaziano,Maria Gazouli,Graham G. Giles,Graham G. Giles,Graham G. Giles,Edward Giovannucci,Michael Goggins,Gary E. Goodman,Phyllis J. Goodman,Thilo Hackert,Christopher A. Haiman,Patricia Hartge,Manal Hasan,Péter Hegyi,Kathy J. Helzlsouer,Joseph M. Herman,Ivana Holcatova,Elizabeth A. Holly,Robert N. Hoover,Rayjean J. Hung,Eric J. Jacobs,Krzysztof Jamroziak,Vladimir Janout,Rudolf Kaaks,Kay-Tee Khaw,Eric A. Klein,Manolis Kogevinas,Charles Kooperberg,Matthew H. Kulke,Juozas Kupcinskas,Robert J. Kurtz,Daniel A. Laheru,Stefano Landi,Rita T. Lawlor,I. Min Lee,Loic LeMarchand,Lingeng Lu,Núria Malats,Andrea Mambrini,Satu Männistö,Roger L. Milne,Roger L. Milne,Beatrice Mohelníková-Duchoňová,Rachel E. Neale,John P. Neoptolemos,Ann L. Oberg,Sara H. Olson,Irene Orlow,Claudio Pasquali,Alpa V. Patel,Ulrike Peters,Raffaele Pezzilli,Miquel Porta,Francisco X. Real,Francisco X. Real,Nathaniel Rothman,Ghislaine Scelo,Howard D. Sesso,Gianluca Severi,Gianluca Severi,Gianluca Severi,Xiao-Ou Shu,Debra T. Silverman,Jill P. Smith,Pavel Soucek,Malin Sund,Renata Talar-Wojnarowska,Francesca Tavano,Mark D. Thornquist,Geoffrey S. Tobias,Stephen K. Van Den Eeden,Yogesh K. Vashist,Kala Visvanathan,Pavel Vodicka,Jean Wactawski-Wende,Zhaoming Wang,Nicolas Wentzensen,Emily White,Emily White,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Wei Zheng,Peter Kraft,Donghui Li,Stephen J. Chanock,Ofure Obazee,Gloria M. Petersen,Laufey T. Amundadottir,Laufey T. Amundadottir +132 more
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TLDR
The largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the PANScan and the Pancreatic Cancer Case Control Consortium (PanC4), was performed in this paper.Abstract:
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10−8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10−14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10−10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10−8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10−8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.read more
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Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium
Michael Goggins,Kasper A. Overbeek,Randall E. Brand,Sapna Syngal,Marco Del Chiaro,Detlef K. Bartsch,Claudio Bassi,Alfredo Carrato,James J. Farrell,Elliot K. Fishman,Paul Fockens,Thomas M. Gress,Jeanin E. van Hooft,Ralph H. Hruban,Fay Kastrinos,Fay Kastrinos,Allison Klein,Anne Marie Lennon,Aimee L. Lucas,Walter G. Park,Anil K. Rustgi,Diane M. Simeone,Elena M. Stoffel,Hans F. A. Vasen,Djuna L. Cahen,Marcia I. Canto,Marco J. Bruno +26 more
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