Heterogeneity of cancer-associated fibroblasts: Opportunities for precision medicine.
Ryu Kanzaki,Kristian Pietras +1 more
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TLDR
Application of newly developed approaches to single‐cell analysis has already made an impact on understanding of the heterogeneity of cancer‐associated fibroblasts and the possibility of novel therapies targeting CAF subsets is discussed.Abstract:
Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor The conventional tumor-cell-centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial Among cells within the TME, cancer-associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF-targeted therapies In this context, application of newly developed approaches to single-cell analysis has already made an impact on our understanding of the heterogeneity of CAFs Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsetsread more
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Journal ArticleDOI
Clinical and therapeutic relevance of cancer-associated fibroblasts.
TL;DR: In this paper, the clinical relevance of CAFs is summarized with an emphasis on their value as prognosis factors and therapeutic targets, including how these complex bimodal functions evolve and are subjugated by neoplastic cells.
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Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
Fanglong Wu,Jin Yang,Junjiang Liu,Ye Wang,Jingtian Mu,Qingxiang Zeng,Shuzhi Deng,Hongmei Zhou +7 more
TL;DR: In this paper, a comprehensive understanding of these signaling cascades in interactions between cancer cells and CAFs is necessary to fully realize the pivotal roles of CAFs in cancers, and three potential targeting strategies, including, epithelial-mesenchymal common targets, sequential target perturbation, and crosstalk-directed signaling targets, paving the way for CAF-directed or host cell-directed antitumor therapy.
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Targeting TGFβ signal transduction for cancer therapy.
TL;DR: A review of the role of transforming growth factor-β (TGFβ) in cancer initiation and progression is presented in this article, which summarizes the recent clinical advancements regarding TGFβ signaling interventions for cancer treatment, and discuss the remaining challenges and opportunities related to targeting this pathway.
Journal ArticleDOI
Cancer associated-fibroblast-derived exosomes in cancer progression.
TL;DR: In this article, the role of exosomes in the communication between CAFs and cancer cells and other cells of the TME is discussed, and the authors elaborate on the mechanisms by which CAFs-derived exosome contribute to cancer progression.
Journal ArticleDOI
CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion
TL;DR: In this paper, the authors summarized the distinct mechanisms about the complex interplay between CAFs and TAMs and highlighted the consequences of such a mutual relationship especially for tumor progression and tumor immune evasion, focusing on the synergistic pleiotropic effects.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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