Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Book ChapterDOI
Rationale for Exogenous Surfactant in Acute Respiratory Distress Syndrome
J. J. Haitsma,B. Lachmann +1 more
TL;DR: Acute Respiratory Distress Syndrome (ARDS) is characterized by respiratory dysfunction including hypoxemia and decreased lung compliance and the definition according to the American-European Consensus Conference on ARDS stipulates that acute onset is defined.
Book ChapterDOI
Aktueller Stand der Behandlung des schweren ARDS einschließlich der Verwendung des extrakorporalen Gasaustausches
K. Lewandowski,K. J. Falke +1 more
TL;DR: Eine eindeutige ursachliche Beziehung dieser Krankheitsbilder zum ARDS kann jedoch in vielen Fallen nicht hergestellt werden.
Book ChapterDOI
Medikamentose Therapie des ARDS
TL;DR: Die Vielzahl der Faktoren, die ein akutes Atemnotsyndrom des Erwachsenen auslosen konnen, and die Komplexitat der beteiligten Pathomechanismen erschweren die Suche nach einem medikamentosen Therapieansatz, der uber die supportive Therapies hinausgreift.
Book ChapterDOI
In Vivo Tests for Evaluation of Pulmonary Surfactant
TL;DR: The question is posed whether the physical characteristics of surfactant, obtained through in vitro studies, can be also be considered as a method of testing a preparation which has to be physiologically active in the lung.
Journal ArticleDOI
Rapid assessment of ventilation by measurement of carbon dioxide elimination during high-frequency ventilation of kittens.
David W. Smith,Lorry R. Frankel,John G. Walker,Eugene Y. Cheng,Keith S. Meredith,Frederick G. Mihm,Ronald L. Ariagno +6 more
TL;DR: It is concluded that direct monitoring of Veco2 during HFV may be a useful clinical monitoring technique, allowing rapid and accurate assessment of the efficiency of ventilation following step changes in ventilation and potentially assisting in optimizing ventilator settings.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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