Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Liver-type fatty acid binding protein in serum and broncho-alveolar lavage in a model of acute respiratory failure because of surfactant depletion--a possible marker for lung damage?
Robert A. Lachmann,S. Werchan,Christian Schachtrup,Jack J. Haitsma,Friedrich Spener,Burkhard Lachmann +5 more
TL;DR: Levels of L‐FABP in serum and broncho‐alveolar lavage during experimental acute respiratory failure (ARF) are determined to evaluate whether this molecule can serve as a marker for lung damage.
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PaO2 oscillations caused by cyclic alveolar recruitment can be monitored in pig buccal mucosa microcirculation.
Klaus Ulrich Klein,Klaus Ulrich Klein,Erik K. Hartmann,Stefan Boehme,Stefan Boehme,M. Szczyrba,Line Heylen,Tanghua Liu,Matthias David,Christian Werner,Klaus Markstaller,Klaus Markstaller,Kristin Engelhard +12 more
TL;DR: This study investigates if PaO2 oscillations can be detected in the pig buccal mucosa microcirculation and finds that it is possible to detect these oscillations within the respiratory cycle.
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Cardiopulmonary effects of the laparoscopic pneumoperitoneum in a porcine model of adult respiratory distress syndrome
William M Greif,R. Armour Forse +1 more
TL;DR: During laparoscopy, animals with ARDS demonstrate further compromise in pulmonary physiologic parameters but overall cardio-respiratory function is preserved.
Journal ArticleDOI
Influence of phosphatidylglycerol on the uptake of liposomes by alveolar cells and on lung function.
TL;DR: The phosphatidylglycerol concentration may play a fundamental role in the surfactant function and metabolism depending on the presence of so-called cofactors like calcium and magnesium; further study is needed to clarify the mechanisms involved.
Journal ArticleDOI
Electrical impedance tomography for non-invasive assessment of stroke volume variation in health and experimental lung injury.
Constantin Trepte,Charles R. Phillips,Josep Solà,Andy Adler,Bernd Saugel,S.A. Haas,Stephan H. Bohm,D.A. Reuter +7 more
TL;DR: EIT provides automated calculation of a dynamic preload index of fluid responsiveness (SVVEIT) that is non-invasively derived from a central haemodynamic signal, however, alterations in thoracic impedance induced by lung injury influence this method.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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