Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Vitamin A Is Systemically Bioavailable After Intratracheal Administration With Surfactant in an Animal Model of Newborn Respiratory Distress
Avash J. Singh,Vadim Bronshtein,Minesh Khashu,Kyle O. Lee,James E. Potts,James K. Friel,Philippe Chessex +6 more
TL;DR: The hypothesis that intratracheal vitamin A administration with surfactant is systemically bioavailable without interfering with the functional properties of exogenous surfactan is tested, which was associated with rapid hepatic uptake.
Journal ArticleDOI
A novel experimental model of acute respiratory distress syndrome in pig.
TL;DR: The present model of the ARDS is clinically relevant and thus it is suitable for further research of the pathophysiology and management of this serious medical condition.
Journal ArticleDOI
Location of the Hydrophobic Surfactant Proteins, SP-B and SP-C, in Fluid-Phase Bilayers
Ryan W. Loney,Sergio Panzuela,Sergio Panzuela,Jespar Chen,Zimo Yang,Jonathan R. Fritz,Zachary Dell,Valentina Corradi,Kamlesh Kumar,D. Peter Tieleman,Stephen B. Hall,Stephanie Tristram-Nagle +11 more
TL;DR: This work used X-ray diffuse scattering (XDS) and molecular dynamics simulations to determine the location of SP-B and SP-C within phospholipid bilayers and provides the most definitive evidence yet concerning the location and orientation of the hydrophobic surfactant proteins.
Journal ArticleDOI
Tidal changes in PaO2 and their relationship to cyclical lung recruitment/derecruitment in a porcine lung injury model.
Douglas C. Crockett,John N. Cronin,Nikhil Bommakanti,Nikhil Bommakanti,Rongsheng Chen,Clive E.W. Hahn,Göran Hedenstierna,Anders Larsson,Andrew D. Farmery,Federico Formenti,Federico Formenti,Federico Formenti +11 more
TL;DR: This study in a porcine model of collapse‐prone lungs did not demonstrate the expected association between PaO2 oscillation amplitude and the degree of recruitment/derecruitment, and suggests that changes in pulmonary ventilation are not the sole determinant of changes in PaO 2 during mechanical ventilation in lung injury.
Journal ArticleDOI
Optimal learning control of oxygen saturation using a policy iteration algorithm and a proof-of-concept in an interconnecting three-tank system
TL;DR: The simulation results demonstrate the optimal control of oxygenation based on the proposed PIA by iteratively evaluating the Hamiltonian cost functions and synthesizing the control actions until achieving the converged optimal criteria.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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