Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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A system for integrated measurement of ventilator settings, lung volume change and blood gases during high-frequency oscillatory ventilation.
TL;DR: A system for integrated measurement of ventilator settings and dependent physiological variables during high-frequency oscillatory ventilation (HFOV) and graphs were obtained, showing the relationship between imposed mean airway pressure and lung volume change, and oxygenation.
Journal ArticleDOI
Preserved spontaneous breathing improves cardiac output during partial liquid ventilation.
TL;DR: It is concluded that during PLV, CO is higher during SB+PAV than during CV+MP, resulting in an improved oxygen delivery, and in surfactant-depleted rabbits, improved CO, oxygen Delivery, and arterial blood pressure resulted in higher pH, possibly reflecting improved tissue perfusion and oxygenation.
Journal ArticleDOI
Exogenous surfactant restores lung function but not peripheral immunosuppression in ventilated surfactant-deficient rats
Harriet A. E. Vreugdenhil,Burkhard Lachmann,Jack J. Haitsma,Jitske Zijlstra,Cobi Jacoba Johanna Heijnen,Nicolaas J. G. Jansen,Adrianus J. van Vught +6 more
TL;DR: Surfactant treatment significantly improved lung function, but could not prevent increased pulmonary expression of MIP-2, IL-1β, and HSP70 and decreased peripheral mitogen-induced lymphocyte proliferation and IFN-γ and IL-10 production in vitro.
Journal ArticleDOI
Inhaled nitric oxide combined with prostacyclin and adrenomedullin in acute respiratory failure with pulmonary hypertension in piglets.
Carlo Dani,Vittorio Pavoni,Iuri Corsini,Mariangela Longini,Gabriele Gori,Lara Giannesello,Avio Perna,Gaetano Gritti,Ferdinando Paternostro,Annalisa Forestieri,Giuseppe Buonocore,Firmino F. Rubaltelli +11 more
TL;DR: The treatment with nitric oxide alone or combined with prostacyclin or ADM were effective in decreasing mean PAP and improving oxygenation in a piglet model of PH, but the combination of aerosolized prostacyClin and ADM with nitRIC oxide might have a role in the treatment of infants with PH refractory to nitricoxide alone.
Journal ArticleDOI
Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury.
John N. Cronin,João Batista Borges,Douglas C. Crockett,Andrew D. Farmery,Göran Hedenstierna,Anders Larsson,Minh C. Tran,Luigi Camporota,Luigi Camporota,Federico Formenti,Federico Formenti +10 more
TL;DR: Overall, dCT closely approximates whole-lung aeration and density, improved by inspiration where a decrease in CT density and atelectasis can be interpreted as physiological rather than artefactual.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
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"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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