Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
Reads0
Chats0
TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
More filters
Journal ArticleDOI
Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung Injury.
John N. Cronin,Douglas C. Crockett,Andrew D. Farmery,Göran Hedenstierna,Anders Larsson,Luigi Camporota,Luigi Camporota,Federico Formenti,Federico Formenti +8 more
TL;DR: In experimental atelectasis with minimal tidal recruitment/derecruitment, mechanical inspiratory breaths redistributed blood volume away from well-ventilated areas, worsening Pao2/Fio2.
Journal ArticleDOI
Decreased Lung Injury after Surfactant in Piglets Treated with Continuous Positive Airway Pressure or Synchronized Intermittent Mandatory Ventilation
Joan L. Nold,Pat A. Meyers,Cathy T. Worwa,Ronald Goertz,Krysta Huseby,Galen Schauer,Mark C. Mammel +6 more
TL;DR: Animals treated with surfactant prior to CPAP or SIMV had less acute lung injury, which suggests, during early ventilatory support, surfactants administration may modulate pulmonary inflammation.
Journal ArticleDOI
Pressure-release tracheal gas insufflation reduces airway pressures in lung-injured sheep maintaining eucapnia.
TL;DR: The ability of continuous-flow TGI to maintain eucapnia while reducing airway pressure and tidal volume and VT is investigated to avoid TGI-generated positive end-expiratory pressure (PEEP).
Journal ArticleDOI
Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model.
Takeshi Yoshida,Doreen Engelberts,Gail Otulakowski,Bhushan H. Katira,Martin Post,Niall D. Ferguson,Niall D. Ferguson,Laurent Brochard,Marcelo B. P. Amato,Brian P. Kavanagh +9 more
TL;DR: Continuous negative abdominal pressure added to PEEP reduces ventilator-induced lung injury in a pig model compared with PEEP alone, despite targeting identical expiratory transpulmonary pressure.
Journal ArticleDOI
Timing of surfactant administration determines its physiologic response in a rabbit model of airway lavage.
Martin F. Krause,Thomas Hoehn +1 more
TL;DR: It is concluded that early surfactant administration elicits a superior response related to gas exchange, lung volume and lung mechanics in this animal model, in line with the more pronounced surfactants effects in the clinical setting when premature infants with RDS are treated using early intervention protocols.
References
More filters
Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
Related Papers (5)
Ventilator-induced lung injury: lessons from experimental studies.
Didier Dreyfuss,Georges Saumon +1 more