Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Validating the inspired sinewave technique to measure the volume of the ‘baby lung’ in a porcine lung-injury model
Douglas C. Crockett,Minh C. Tran,Federico Formenti,Federico Formenti,Federico Formenti,John N. Cronin,Göran Hedenstierna,Anders Larsson,Phi Anh Phan,Andrew D. Farmery +9 more
TL;DR: Investigating a modified gas-dilution method, the inspired sinewave technique (IST), to measure the effective lung volume in pigs with uninjured lungs and in an ARDS model shows minimal bias when tracking PEEP-induced changes in lung volume compared with CT in a saline-lavage model of ARDS.
Journal ArticleDOI
Circulatory changes after surfactant bolus instillation in lung-lavaged adult rabbits.
TL;DR: The results suggest that a peripheral vasodilatation is the most likely cause for the drop in mean arterial blood pressure (MABP) in infants treated for respiratory distress syndrome.
Journal ArticleDOI
High frequency oscillatory ventilation near resonant frequency of the respiratory system in rabbits with normal and surfactant depleted lungs
TL;DR: High frequency oscillatory ventilation produced effective pulmonary gas exchange but did not improve arterial oxygenation in comparison with CMV at matched MAPs both before and after surfactant depletion.
Journal ArticleDOI
Utilization of the lower inflection point of the pressure-volume curve results in protective conventional ventilation comparable to high frequency oscillatory ventilation in an animal model of acute respiratory distress syndrome
Felipe de Souza Rossi,Renata Suman Mascaretti,Luciana Bertocco de Paiva Haddad,Norberto Antonio Freddi,Thais Mauad,Celso Moura Rebello +5 more
TL;DR: Utilization of the lower inflection point of the pressure-volume curve in the ventilation strategies considered in this study resulted in comparable efficacy with regards to oxygenation and hemodynamics, a high PaCO2 level and a lower pH.
Book ChapterDOI
Surfactant in pulmonary oxygen toxicity.
TL;DR: The present study was designed to investigate the role of pulmonary surfactant in the development of respiratory failure induced by high concentrations of oxygen.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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