Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Closed-loop control of extracorporeal oxygen and carbon dioxide gas transfer
Christian Brendle,K.-F. Hackmack,Jan Kühn,M.N. Wardeh,Thorsten Janisch,R. Kopp,Rolf Rossaint,André Stollenwerk,Stefan Kowalewski,Steffen Leonhardt,Marian Walter,Berno J. E. Misgeld +11 more
TL;DR: The control system was first evaluated in silico and then in vivo using an animal model and was shown to be feasible and its response time is sufficient to meet patients' clinical needs.
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Development of an experimental model of an acute respiratory failure by intratracheal sea water infusion: a comparison with a conventional oleic acid induction.
TL;DR: An experimental model of acute respiratory failure developed in dogs by endotracheal sea water infusion will provide many advantages over the conventional one using oleic acid, and will be useful for studying the pathophysiology of ARF and its therapeutic strategies, such as extracorporeal membrane oxygenation and/or carbon dioxide removal.
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Impaired energy metabolism and altered functional activity of alveolar type II epithelial cells following exposure of rats to nitrogen mustard.
Vasanthi R. Sunil,Kinal N. Vayas,Jared Radbel,Elena Abramova,A M Gow,Jeffrey D. Laskin,Debra L. Laskin +6 more
TL;DR: In this article , the effects of nitrogen mustard (NM) exposure on Type II cells were assessed, showing that double strand DNA breaks were associated with decreased expression of the DNA repair protein, PARP1.
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Injury to the Developing Lung: experimental and clinic al aspects
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References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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