Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury
Emilia Boerger,Martin Russ,Philip von Platen,Mahdi Taher,Lea Hinken,Anake Pomprapa,R. Koebrich,Frank Konietschke,Jan A. Graw,Burkhard Lachmann,Wolfgang Braun,Steffen Leonhardt,Philipp A. Pickerodt,Roland C. E. Francis +13 more
TL;DR: In this article , a porcine lung injury was induced by lung lavage and 3 h of either protective or injurious ventilation, followed by 3 hours of protective ventilation (N = 6 per group).
Proceedings ArticleDOI
Validating the Inspired Sinewave Technique to Measure Lung Heterogeneity Compared to Atelectasis & Over-Distended Volume in Computed Tomography Images
Minh C. Tran,Phi-Anh Phan,Douglas C. Crockett,Federico Formenti,John N. Cronin,Stephen J. Payne,Andrew D. Farmery +6 more
TL;DR: The inspired sinewave technique (IST) is a non-invasive nonionising method which can measure accurately lung parameters as discussed by the authors, and has the potential to measure the lung heterogeneity in ARDS animals.
Journal ArticleDOI
Oxygen delivery and consumption in surfactant-depleted newborn piglets
TL;DR: The data suggest that O2 supply dependency is present in surfactant-depleted newborn piglets and is correlated with the decrease in DO2.
Injury in Early Experimental Acute Respiratory Distress Syndrome
Nicolas de Prost,Yan Feng,Tyler J. Wellman,Mauro R. Tucci,Eduardo L. V. Costa,Guido Musch,Tilo Winkler,R. Scott Harris,Jose G. Venegas,Wei Chao,Marcos F. Vidal Melo +10 more
TL;DR: Pulmonary metabolism assessed with 18F-FDG PET depends on the mechanism of injury and appears to be additive for endotoxemia and surfactant depletion, and may be a valuable imaging biomarker of early lung injury.
References
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Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
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Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
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"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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