Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
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Book ChapterDOI
Permissive Hyperkapnie und extrakorporaler Gasaustausch
TL;DR: Das schwere akute Lungenversagen des Erwachsenen, in der englischsprachigen Erstbeschreibung als “adult respiratory distress syndrome” (ARDS) bezeichnet, ist durch eine anhaltende, ausgepragte Storung des pulmonalen Gasaustausches, einen extremen Abfall der Lungencompliance and ein radiologisch erf
CritiCal Care MediCine
TL;DR: Pone positioning during mechanical ventilation for patients with acute lung injury has been shown to increase oxygenation and possibly improve outcome and its use during spontaneous ventilation has increased as result of the pandemic, yet details on its ventilatory effects have not been well established.
Journal ArticleDOI
Ontario Poison Control Pediatric Call Data: Who, What, When, Where, Why, and How
DissertationDOI
Validação de um modelo suíno da síndrome do desconforto respiratório agudo (SDRA) grave e persistente
Journal ArticleDOI
High resolution propagation-based lung imaging at clinically relevant X-ray dose levels
Jonas Albers,Willi L. Wagner,Mascha O Fiedler,A. Rothermel,Felix Wünnemann,F. Di Lillo,Diego Dreossi,Nicola Sodini,Elisa Baratella,Marco Confalonieri,Fulvia Arfelli,Armin Kalenka,Joachim Lotz,Jürgen Biederer,Mark O. Wielpütz,Hans-Ulrich Kauczor,Frauke Alves,Giuliana Tromba,Christian Dullin +18 more
TL;DR: Propagation-based imaging (PBI) is a phase sensitive X-ray imaging technique capable of reaching high spatial resolutions at relatively low applied radiation dose levels as mentioned in this paper , which is the current imaging method of choice in the diagnosis of lung diseases.
References
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Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
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Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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