Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
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DissertationDOI
Estudo de três estratégias de ventilação artificial protetora: alta freqüência, baixa freqüência e baixa freqüência associada à insuflação de gás traqueal, em modelo experimental de SARA
Functional residual capacity Development of new monitoring techniques for critically ill patients
TL;DR: Combined measurements of changes in lung volume and compliance could be helpful to define responders and non-responders to lung recruitment manoeuvres, and to increases in positive end-expiratory pressure (PEEP).
Dissertation
Evaluation and development of a capnodynamic method for estimation of pulmonary blood flow in a porcine model
TL;DR: This capnodynamic method could be considered a non-invasive alternative for estimation of EPBF and ELV in mechanically ventilated subjects without significant lung pathology and might have the prerequisite to be used to guide goal-directed treatment protocols for CO optimisation.
Journal ArticleDOI
Extracorporeal CO2 Removal in a Lung Lavage Model of Respiratory Failure
TL;DR: The authors evaluated ECCO2R in conjunction with low-frequency ventilation, using a lung lavage-induced model of respiratory failure in rabbits, meeting the criteria for respiratory failure.
Journal ArticleDOI
Effects of low dose intravenous sodium nitrite on arterial oxygenation and hemodynamics in experimental acute respiratory distress syndrome (ARDS)
Sebastian Kronfeldt,P Lother,Rce Francis,Thilo Busch,Willehad Boemke,Philipp A. Pickerodt,Erik R. Swenson,Erik R. Swenson +7 more
TL;DR: It is shown that sodium nitrite (NaNO2) mitigates ventilator-induced lung injury via NO dependent mechanisms in rats via NOdependent mechanisms through NaNO dependent mechanisms.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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