Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs
Yoshiko Kawai,Kumiko Ajima,Maki Kaidoh,Masao Sakaguchi,Satoshi Tanaka,Mikito Kawamata,Hiroko Kimura,Toshio Ohhashi +7 more
TL;DR: The validity of the proposed concept of CO2 gas exchange in the lungs is reaffirm by reaffirming that in the presence of less severe anemia both the PeCO2 and SAP fell significantly when the rabbits' blood viscosity was decreased.
Journal ArticleDOI
Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test.
Minh C. Tran,Minh C. Tran,Vu Nguyen,Richard M. Bruce,Douglas C. Crockett,Federico Formenti,Federico Formenti,Federico Formenti,Phi Anh Phan,Stephen J. Payne,Andrew D. Farmery +10 more
TL;DR: A simulation-based optimisation for the Inspired Sinewave Test (IST) was developed, with a simulation of a realistic heterogeneous lung, namely a lognormal distribution of spatial ventilation and perfusion, permitting diagnostic distinction between health and disease states.
Journal ArticleDOI
Potential use of warm butyl alcohol vapor as adjunct agent in the emergency treatment of sea water wet near-drowning
TL;DR: The inspired vapor of butanol was much more effective in elevation of arterial blood oxygen pressures when combined with oxygen therapy over the values found when 100% water vapor-oxygen treatments were given.
Book ChapterDOI
Pressure-Volume Relationship in the Injured Lung
TL;DR: Measurements of the inspiratory pressure-volume curves of the respiratory system have been used in mechanically ventilated patients with ALI as a means of assessing their status and progress and to optimize the use of positive end-expiratory pressure (PEEP) and of mechanical ventilation.
Titrating Open Lung PEEP in Acute Lung Injury : A clinical method based on changes in dynamic compliance
TL;DR: The recognition that supportive mechanical ventilation can also damage the lung, the so called ventilation induced lung injury (VILI), has revived the more than 40 year long debate on the optimal way to ventilation.
References
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Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
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"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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