Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Impact of Different Positive End-Expiratory Pressures on Lung Mechanics in the Setting of Moderately Elevated Intra-Abdominal Pressure and Acute Lung Injury in a Porcine Model.
Mascha O Fiedler,Emilis Simeliunas,B. Luise Deutsch,Dovile Diktanaite,Alexander Harms,Maik Brune,Maximilian Dietrich,Florian Uhle,Markus A. Weigand,Armin Kalenka +9 more
TL;DR: In this article, the effects of a moderately elevated intra-abdominal pressure (IAP) on lung mechanics in acute respiratory distress syndrome (ARDS) have still not been fully analyzed, and the optimal positive end-expiratory pressure (PEEP) in elevated IAP and ARDS is unclear.
Journal ArticleDOI
Lung image changes during bronchopulmonary lavage estimated using transoesophageal echocardiography.
TL;DR: Transoesophageal echocardiography can yield useful information about the lung during bronchopulmonary lavage, and there was a significant relationship between the percentage venous admixture and air-free area during lavage.
Journal ArticleDOI
Extracorporeal CO2 Removal in a Lung Lavage Induced Respiratory Distress Syndrome
TL;DR: Ten pigs with experimental respiratory distress syndrome treated by extracorporeal CO2 removal (ECCO2-R) combined with low frequency positive pressure ventilation (LPPV) driven by a simple renal perfusion system allows adequate gas exchange in experimental respiratory failure.
Journal ArticleDOI
Total and prolonged filling of the lungs with Ringer's solution under extracorporeal lung assist (ECLA) in dogs.
Yuji Sakanashi,Hironari Tanimoto,Taisuke Okamoto,Masafumi Tashiro,Hushan Ao,Hidenori Terasaki +5 more
TL;DR: It is not known whether the lung can recover gas exchange ability after prolonged fluid filling, but it is possible to sustain gas exchange without the natural lung by using extracorporeal circulation and an artificial lung.
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Respirator System For Total Liquid Ventilation
M A Gomez,Enrique Hilario,Francisco J. Alvarez,Elena Gastiasoro,Antonia Alvarez,J.L. Larrabe +5 more
TL;DR: Improvements in gas exchange and lung mechanics were observed during liquid ventilation, without impairment of cardiovascular profiles, and the computerized system demonstrated its ability to monitor in vivo lung mechanics, providing valuable data for early decision-making.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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