Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
Reads0
Chats0
TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
More filters
Journal ArticleDOI
Pharmacological properties and therapeutic activity of Russian-manufactured pulmonary surfactants
O. A. Rozenberg,L. N. Danilov,V. A. Volchkov,E. S. Lebedeva,V. F. Dubrovskaya,A. A. Valkovich,O. V. Klestova,Yu. A. Kirillov,A. A. Seiliev,A. A. Shaldzhyan,L. V. Loshakova,A E Shul'ga,A. G. Zhuikov +12 more
TL;DR: Three pulmonary surfactant preparations: from human amniotic fluid, from bronchoalveolar lavage fluid, and from cattle lung tissue homogenate were tested in preclinical studies and showed nontoxic, posses no mutagenic, teratogenic, and allergic activities and do not modify visceral morphology after repeated injections.
Journal ArticleDOI
Serial bronchoalveolar lavage of preterm infants is not associated with chest radiological changes.
TL;DR: Repeated non-bronchoscopic bronchoalveolar lavage in newborn infants does not appear to be associated with radiological changes suggesting that surfactant is not constantly removed.
Journal ArticleDOI
Comparison of Work of Breathing Between Noninvasive Ventilation and Neurally Adjusted Ventilatory Assist in a Healthy and a Lung-Injured Piglet Model
Michelle L Jones,Michelle L Jones,Shasha Bai,Tracy L. Thurman,Shirley J Holt,Mark J Heulitt,Sherry E. Courtney,Sherry E. Courtney +7 more
TL;DR: The pressure-time product was significantly decreased for NIV-NAVA in both healthy and injured lungs (P < .001).
Journal ArticleDOI
Inhaled nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions.
TL;DR: Inhaled NO during PLV shifted the pulmonary blood flow to the non-dependent region and improved pulmonary gas exchange, suggesting that inhaled NO took effect predominantly in theNon- dependent region duringPLV.
Journal ArticleDOI
High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α.
TL;DR: The feedback relationship between reactive oxygen species and HIF-1 plays an essential role in improving cell viability and it is anticipated that the emulsion will be applied in the field of alleviating hypoxemia.
References
More filters
Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
Related Papers (5)
Ventilator-induced lung injury: lessons from experimental studies.
Didier Dreyfuss,Georges Saumon +1 more