Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Hemodynamics of respiratory failure in rabbit model: effect of surfactant supplementation.
TL;DR: According to the present results, blood pressure and CO may decrease acutely when exogenous surfactant is administered coincidental with blood loss.
Non-invasive respiratory monitoring in surgical intensive care
TL;DR: The need to monitor postsurgical patients for signs of respiratory deterioration was recognized long before the first intensive care units were introduced during World War II, and these experiences probably mark the beginning of the development of techniques to monitor the respiratory condition of patients after surgery.
Book ChapterDOI
Effects of different inspiratory/expiratory (I/E) ratios and PEEP-ventilation on blood gases and hemodynamics in dogs with severe respiratory distress syndrome (RDS).
TL;DR: The main immediate therapeutic goal in severe ARDS consists of attempting to overcome hypoxaemia as well as metabolic and respiratory acidosis by means of respiratory therapy, increased inspiratory oxygen concentration and infusion of buffer solution.
Journal ArticleDOI
Airway Pathological Alterations Selectively Associated With Acute Respiratory Distress Syndrome and Diffuse Alveolar Damage - Narrative Review.
TL;DR: This narrative review is focused on pathological airway changes associated to Diffuse Alveolar Damage in the context of Acute Respiratory Distress Syndrome and why it is necessary to study airway features associated to DAD in patients with ARDS.
Journal ArticleDOI
Aerosolized surfactant therapy for endotoxin-induced experimental acute respiratory distress syndrome in rats
Katsumi Tashiro,Keisuke Yamada,T. Konzaki,Ken Yamamoto,S. Ohmura,Tsutomu Kobayashi,Yasuhiro Suzuki +6 more
TL;DR: It is concluded that improvement in gas exchange as a result of inhalation of MNS depends on the duration of inhalations.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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