Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
Reads0
Chats0
TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
More filters
Journal ArticleDOI
Compliance Is Nonlinear over Tidal Volume Irrespective of Positive End-Expiratory Pressure Level in Surfactant-Depleted Piglets
Michael Lichtwarck-Aschoff,Georg Mols,A Hedlund,V. Kessler,Agneta Markström,Josef Guttmann,Göran Hedenstierna,Ulf Sjöstrand +7 more
TL;DR: It is concluded that a PEEP that results in constant compliance over the full VT range is difficult to find, and cannot be derived from conventional respiratory-mechanical analyses; nor does this PEEP level coincide with maximal gas exchange.
Journal ArticleDOI
Superimposing positive end-expiratory pressure during partial liquid ventilation in experimental lung injury
TL;DR: It was concluded that in experimental lung injury, positive end-expiratory pressure provided alveolar recruitment and significantly augmented oxygenation and might eventually allow either a reduce in the volumes of perfluorocarbons required, or a reduction in positive end of-expiration pressure necessary to maintain pulmonary gas exchange in acute lung injury.
Journal ArticleDOI
Perfluorocarbon broncho-alveolar lavage and liquid ventilation versus saline broncho-alveolar lavage in adult guinea pig experimental model of meconium inhalation
Giuseppe A. Marraro,Maurizio Bonati,A. Ferrari,M. M. Barzaghi,C. Pagani,Angela Bortolotti,A. Galbiati,Marco Luchetti,A. Croce +8 more
TL;DR: In saline-BAL treated animals, the lung structure appeared severely compromised with the presence of meconium in bronchioles and alveoli, intra-alveolar oedema and haemorrhagic areas, and by contrast, PFC-B AL and TLV by gravity seemed to prevent absorption of me Conium, facilitate its removal, improve gas exchange and reduce lung barotrauma.
Journal ArticleDOI
Ventilation with Constant Versus Decelerating Inspiratory Flow in Experimentally Induced Acute Respiratory Failure
TL;DR: The decelerating inspiratory flow pattern increased carbon dioxide elimination, without any reduction of inspiratory airway pressure or apparent improvement in arterial oxygen tension, as well as improving alveolar ventilation.
Journal ArticleDOI
Comparative effects of proportional assist and variable pressure support ventilation on lung function and damage in experimental lung injury.
Peter M. Spieth,Andreas Güldner,Alessandro Beda,Nadja C. Carvalho,Thomas Nowack,Anke Krause,Ines Rentzsch,Sabina Suchantke,Serge C. Thal,Kristin Engelhard,Michael Kasper,Thea Koch,Paolo Pelosi,Marcelo Gama de Abreu +13 more
TL;DR: In a lung lavage model of acute lung injury, both variable pressure support and proportional assist ventilation increased the variability of tidal volume and improved oxygenation and venous admixture, without influencing subject-ventilator synchrony or affecting lung injury compared with pressure support ventilation.
References
More filters
Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
Related Papers (5)
Ventilator-induced lung injury: lessons from experimental studies.
Didier Dreyfuss,Georges Saumon +1 more