Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
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Journal ArticleDOI
Physiological, Biochemical, and Biophysical Characterization of the Lung-Lavaged Spontaneously-Breathing Rabbit as a Model for Respiratory Distress Syndrome.
Francesca Ricci,Chiara Catozzi,Xabier Murgia,Brenda Rosa,Davide Amidani,Luca Lorenzini,Federico Bianco,Claudio Rivetti,Silvia Catinella,Gino Villetti,Maurizio Civelli,Barbara Pioselli,Carlo Dani,Fabrizio Salomone +13 more
TL;DR: The surfactant-depleted adult rabbit RDS model proved to be a valuable and efficient preclinical tool for mimicking the clinical scenario of preterm infants affected by mild/moderate RDS who spontaneously breathe and do not require mechanical ventilation.
Journal ArticleDOI
Effect of inhaled nitric oxide in combination with almitrine on ventilation-perfusion distributions in experimental lung injury.
TL;DR: It is concluded that NO + ALM results in an additive improvement of pulmonary gas exchange in an experimental model of ALI by diverting additional blood flow from non-ventilated lung regions towards those with normal V˙.A/Q˙ relationships.
Journal ArticleDOI
High-frequency oscillatory ventilation is not superior to conventional mechanical ventilation in surfactant-treated rabbits with lung injury.
TL;DR: It is concluded that the use of surfactant therapy in combination with high-frequency oscillatory ventilation is not superior to conventional mechanical ventilation in improving gas exchange, lung deflation stability and in the prevention of lung injury, if lungs are kept expanded.
Journal ArticleDOI
Angiotensin II receptor inhibition prevents pneumocyte apoptosis in surfactant-depleted rat lungs.
Heikki Lukkarinen,Jukka Laine,Heikki J. Aho,Alexander Zagariya,Dharmapuri Vidyasagar,Pekka Kääpä +5 more
TL;DR: The results suggest that increased epithelial apoptosis in surfactant‐deficient lungs is mediated by ANG II receptor (specifically, subtype 1) action.
Journal ArticleDOI
Nitric Oxide Contributes to Surfactant-Induced Vasodilatation in Surfactant-Depleted Newborn Piglets
TL;DR: It is concluded that the vasodilatory effect of porcine surfactant instillation in newborn piglets with Surfactant deficiency is associated with activation of NO synthase.
References
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Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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