Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
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Pressure support ventilation and biphasic positive airway pressure improve oxygenation by redistribution of pulmonary blood flow.
Alysson R. Carvalho,Peter M. Spieth,Paolo Pelosi,Alessandro Beda,Agnaldo José Lopes,Boriana Neykova,Axel R. Heller,Thea Koch,Marcelo Gama de Abreu +8 more
TL;DR: In this model of ALI, the improvements of oxygenation and venous admixture obtained during assisted mechanical ventilation with PSV and BIPAP + SB were explained by the redistribution of PBF toward nondependent lung regions rather than recruitment of dependent zones.
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Relation between Shunt, Aeration, and Perfusion in Experimental Acute Lung Injury
Guido Musch,Giacomo Bellani,Marcos F. Vidal Melo,R. Scott Harris,Tilo Winkler,Tobias Schroeder,Jose G. Venegas +6 more
TL;DR: Most of the interanimal variability in global shunt fraction could be explained by the combined effect of this relation and the distribution of perfusion on regional shunt, rather than by differences in global aeration.
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Higher Levels of Spontaneous Breathing Induce Lung Recruitment and Reduce Global Stress/Strain in Experimental Lung Injury
Andreas Güldner,Anja Braune,Nadja C. Carvalho,Alessandro Beda,Stefan Zeidler,Bärbel Wiedemann,Gerd Wunderlich,Michael Andreeff,Christopher Uhlig,Peter M. Spieth,Thea Koch,Paolo Pelosi,Jörg Kotzerke,Marcelo Gama de Abreu +13 more
TL;DR: In a saline lung lavage model of experimental acute respiratory distress syndrome in pigs, levels of SB during BIPAP/APRV higher than currently recommended for clinical practice, that is, 10 to 30%, improve oxygenation by increasing aeration in dependent lung zones without relevant redistribution of perfusion.
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Combining partial liquid ventilation with nitric oxide to improve gas exchange in acute lung injury.
TL;DR: PLV can be combined with NO administration and results in a cumulative effect on arterial oxygenation and to a decrease in pulmonary artery pressure, without having any deleterious effect on measured systemic hemodynamic parameters.
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Aerosolized Versus Instilled Exogenous Surfactant in a Nonuniform Pattern of Lung Injury
James F. Lewis,Lynda McCaig +1 more
TL;DR: Both the underlying pattern of lung injury and the exogenous surfactant delivery technique may influence clinical responses to surfactants therapy in patients with the adult respiratory distress syndrome (ARDS).
References
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Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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