Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Exhalation time effects on arterial and venous blood oxygen content and arterial PCO2 during high frequency jet ventilation of surfactant-depleted cats.
TL;DR: The lungs of ten cats were lavaged with 30 ml/kg of saline six times, then sampled arterial and venous blood while the animals were ventilated conventionally at 30 BPM and then with HFJV at 600 BPM, varying inspiratory/expiratory ratios (I/E) from 1:1 to 1:5.
Mechanisms of ventilation-induced lung injury : role of surfactant
TL;DR: Data indicate a beneficial effect of surfactant on ventilation-induced lung injury and prevents impainnent of oxygenation, lung mechanics and minimal surface tension of BAL fluid and reduces Evans blue pemleability.
Dissertation
Oxidants and antioxidants in the pathogenesis of chronic lung disease of prematurity
TL;DR: The BALF: plasma ratio was higher in the RDS group at 4 days o f age than in the CLD group, suggesting that more mature infants have a better ability to concentrate ascorbate in their lungs.
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Quantification of lobar gas exchange: a proof-of-concept study in pigs
Jack Gallifant,John N. Cronin,John N. Cronin,Federico Formenti,Federico Formenti,Federico Formenti +5 more
Journal ArticleDOI
Contrast media inhibit exogenous surfactant therapy in rats with acute respiratory distress syndrome.
TL;DR: The objective is to test the effects of various contrast media on the pulmonary surfactant system and to establish a baseline for this type of study.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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