Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Journal ArticleDOI
Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease
Ryan Brown,Michelle Paulsen,Simone Schmidt,Jolanthe Schatterny,Angela Frank,Stephanie Hirtz,Rebecca Delaney,Declan Doherty,Matthias Hagner,Cliff Taggart,Sinéad Weldon,Marcus A. Mall,Marcus A. Mall +12 more
TL;DR: It is concluded that IL-1R signaling is implicated in airway eosinophilia independent of type 2 cytokines in juvenile Scnn1b-Tg mice, which may be mediated by ICAM-1 dependent transmigration of eos inophils into the lungs.
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A study of experimental acute lung injury in pigs on zero end-expiratory pressure.
TL;DR: Tidal EFL was not detected in experimental ALI, casting some doubt about the usefulness of some experimental models of ALI to mimic some reported findings in human ALI.
Journal ArticleDOI
Non-invasive ventilation and surfactant treatment as the primary mode of respiratory support in surfactant-deficient newborn piglets
Carmen Rey-Santano,Victoria E. Mielgo,Miguel Angel Gomez-Solaetxe,Francesca Ricci,Federico Bianco,Fabrizio Salomone,B Loureiro,Jon López de Heredia y Goya +7 more
TL;DR: In spontaneously breathing SF-deficient newborn piglets, NIPPV is a suitable NIV strategy that improves pulmonary status providing extra protection against pulmonary injury, and all NIV-treated groups showed low brain injury scores.
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A comparison of the hemodynamic and respiratory effects of surfactant instillation during interrupted ventilation versus noninterrupted ventilation in rabbits with severe respiratory failure.
TL;DR: Avoiding interruption of ventilation during surfactant instillation tends to prevent the potential adverse effects of a rapid rise in cerebral blood flow, and furthermore, tends to improve uniformity of Surfactant distribution, whereas having no detrimental effect on respiratory function.
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Alternative protocol to initiate high-frequency oscillatory ventilation: an experimental study.
TL;DR: This HFOV protocol is easy to perform, and allows a fast determination of an adequate TPP level that preserves oxygenation, and systemic hemodynamics, as a measure of safety, showed no relevant deterioration throughout the procedure.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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