Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
Reads0
Chats0
TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
More filters
Journal ArticleDOI
Protective strategies of high-frequency oscillatory ventilation in a rabbit model.
TL;DR: It is concluded that both frequencies of HFOV efficiently restored O2 and CO2 exchange in a rabbit model of severe lung injury, and that 5 Hz HFOv increased neutrophil infiltration relative to 15 Hz H FOV.
Journal ArticleDOI
Oxygenation effect of interventional lung assist in a lavage model of acute lung injury: a prospective experimental study
Günther Zick,Inéz Frerichs,Dirk Schädler,Gunnar Schmitz,Sven Pulletz,Erol Cavus,Felix Wachtler,Jens Scholz,Norbert Weiler +8 more
TL;DR: Oxygenation is increased by ILA in severe lung injury, and the results indicate that the ILA use may not be justified if the improvement of oxygenation is the primary therapy goal.
Journal ArticleDOI
Key questions in ventilator management of the burn-injured patient (second of two parts).
TL;DR: While tidal volume reduction and application of end expiratory pressure are being studied and refined in contemporary ventilation strategies, alternative modes of ventilation designed to better match respiratory demand are also in development.
Journal ArticleDOI
VTCO2 and dynamic compliance-guided lung recruitment in surfactant-depleted piglets: a computed tomography study.
TL;DR: The lung recruitment maneuver was effective and lungs optimally recruited at maximal VTCO2 and that a minimal amount of normally aerated lung was added by further increase in EIP.
Journal ArticleDOI
Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury
Beth N. Shashikant,Thomas L. Miller,Thomas L. Miller,Mei Jy Jeng,Jonathan M. Davis,Thomas H. Shaffer,Thomas H. Shaffer,Marla R. Wolfson +7 more
TL;DR: PLV, with a single dose of higher viscosity and lower vapor pressure PFC, resulted in significantly improved gas exchange and lung mechanics with significant reduction in lung inflammation compared with conventional mechanical ventilation alone and PLV with lower viscosities and higher vapor pressure liquid.
References
More filters
Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
Related Papers (5)
Ventilator-induced lung injury: lessons from experimental studies.
Didier Dreyfuss,Georges Saumon +1 more