Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
Citations
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Standardized lung recruitment during high frequency and conventional ventilation: similar pathophysiologic and inflammatory responses in an animal model of respiratory distress syndrome.
Ramesh K. M. Krishnan,Pat A. Meyers,Cathy T. Worwa,Ronald Goertz,Galen Schauer,Mark C. Mammel +5 more
TL;DR: Using a standardized lung recruitment strategy during both high frequency oscillation and volume-targeted conventional ventilation in spontaneously breathing piglets with surfactant washout, CV+V produced equivalent pathophysiologic outcomes without an increase in proinflammatory cytokines when compared to HFO.
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Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS).
Martin Russ,Sebastian Kronfeldt,Willehad Boemke,Thilo Busch,Roland C. E. Francis,Philipp A. Pickerodt +5 more
TL;DR: This model induction of lung injury with lung lavages does not require the injection of pathogens/endotoxins that impact on measurements of pro- and anti-inflammatory cytokines and has the high recruitability of atelectatic lung tissue.
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Perfluorocarbons attenuate oxidative lung damage
Carlo Dani,Maria Laura Costantino,Elena Martelli,C. Corno,Gianfranco Beniamino Fiore,Giuseppe Buonocore,Mariangela Longini,A. Di Filippo,S. Tozzini,Firmino F. Rubaltelli +9 more
TL;DR: It is concluded that animals treated with TLV showed lower oxidative lung damage compared to animals treating with CMV, which was significantly higher at 4 hr than at baseline.
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In vivo microscopy in a porcine model of acute lung injury
Johannes Bickenbach,Michael Czaplik,Rolf Dembinski,Paolo Pelosi,Wolfgang Schroeder,Gernot Marx,Rolf Rossaint +6 more
TL;DR: A significant deterioration in oxygenation and ventilation-perfusion distribution could be seen being restored after PEEP adjustment, and the VAI may help to assess regional inhomogeneity of the acutely injured lung.
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Peritoneal Ventilation: An Animal Model of Extrapulmonary Ventilation in Experimental Adult Respiratory Distress Syndrome
TL;DR: The study shows that peritoneal ventilation is significantly effective in oxygenation of hypoxemic animals with ARDS and is also effective for carbon dioxide elimination.
References
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Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
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Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
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"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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