Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
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TLDR
Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.Abstract:
Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage procedure induces a condition similar to the adult respiratory distress syndrome. We propose that our technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation which have been suggested for treatment of this disease.read more
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DissertationDOI
Überlebensrate von perfluorocarbonbeatmeten Schweinen mit experimentellem ARDS
TL;DR: It was showed that partial liquid ventilation improved oxygenation not in all animals treated with perfluorocarbons, while these animals showed no improved in oxygenation they survived longer than the controls and the significant improvement in survival time shows a positive effect in the treatment of ARDS.
Benefits of Spontaneous Breathing : Compared with Mechanical Ventilation
TL;DR: Despite attenuating any vasoconstriction, unexpectedly, pulmonary shunt was lower during spontaneous breathing than during MV, suggesting a mechanism active during SB, favorably redistributing pulmonary blood flow and not silenced by SNP.
Journal ArticleDOI
Necrotizing Tracheobronchitis (NTB) Following High Frequency Ventilation: Role of an Angiotensin Converting Enzyme Inhibitor
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Computer-Assisted Piston-Driven Ventilator for Total Liquid Breathing
M A Gomez,Enrique Hilario,Francisco J. Alvarez,Elena Gastiasoro,Antonia Alvarez,J.A. Casla,Jorge Arguinchona,J.L. Larrabe +7 more
TL;DR: Improvements in gas exchange and lung mechanics were observed during liquid ventilation, without impairment of cardiovascular profiles, and the computerized system demonstrated its ability to monitor in vivo lung mechanics, providing valuable data for early decision-making.
Journal ArticleDOI
Experimental studies on lung mechanics, gas exchange and oxygen delivery under open lung conditions. Mechanical ventilation with decelerating versus constant inspiratory flow.
TL;DR: Experimental studies on lung mechanics, gas exchange and oxygen delivery under open lung conditions : mechanical ventilation with decelerating versus constant inspiratory flow.
References
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Journal ArticleDOI
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
Journal Article
Pathogenesis of bronchopulmonary dysplasia following hyaline membrane disease.
A. Taghizadeh,E. O. Reynolds +1 more
TL;DR: It is concluded that the most important factor in the pathogenesis of BPD following HMD is mechanical trauma to the lung from the use of excessively high peak airway pressures during mechanical ventilation.
Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
TL;DR: It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.
Journal ArticleDOI
Effect of pulmonary lavage on lung lecithin synthesis in the Syrian hamster.
TL;DR: Bronchopulmonary lavage with 0.15 m saline stimulated the uptake of [1,2-14C]choline into both the surface-active dipalmitoyl lecithin (DPL) and the unsaturated leCithins (UPC) of Syrian hamster lung, consistent with the view that alveolar lecitins are secreted by the tissue into the alveoli and that unsaturatedLecithins are the precurs
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