Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Exploring the Links Between Seasonal Variation and Spider Foraging
Dantas Whitney,Thomas Edward +1 more
TL;DR: It is revealed that spiders do exhibit selective feeding throughout the year, and appear to do so in a way that diversifies their diets, which suggests opportunity for growth during this uncompetitive period is paramount to accumulating survivorship-increasing, but also mobility-decreasing, cryoprotectants.
Dissertation
Gestion des populations par piégeage de masse en vergers et étude de la spécialisation d'hôte chez les diptères Tephritidae
TL;DR: La hierarchie observee dans les performances larvaires de chaque espece de Tephritidae peut etre expliquee en partie par the composition biochimique des fruits hotes, mais doit faire partie d'une approche de lutte integree incluant des systemes de bait station and de piegeage de masse.
Posted ContentDOI
Malaria mosquitoes acquire and allocate cattle urine to enhance life history traits
Mengistu Dawit,Mengistu Dawit,Mengistu Dawit,Sharon R. Hill,Göran Birgersson,Habte Tekie,Rickard Ignell +6 more
TL;DR: Females actively imbibe cattle urine, and its main nitrogenous compound, urea, and allocate these resources according to life history trade-offs to flight, survival or reproduction, as a function of physiological state, which affects vectorial capacity by increasing daily survival and vector density.
Journal ArticleDOI
Questioning the roles of resources nutritional quality in ecology
TL;DR: In this paper , the authors present a survey of the current landscape of resources nutritional quality research in ecology, focusing on a subset of articles exemplifying the diversity of variables by which resources quality is quantified, and propose some perspectives on the integration of nutritional quality within broader ecological concepts.
Journal ArticleDOI
Trade-offs between cost of ingestion and rate of intake drive defensive toxin use
Tyler E. Douglas,Sofia G. Beskid,Callie E. Gernand,Brianna E. Nirtaut,Kristen E. Tamsil,Richard W. Fitch,Rebecca D. Tarvin +6 more
TL;DR: It is found that ingesting nicotine increased A4 but not A3 fly survival against Leptopilina heterotoma wasp parasitism, and enhanced toxin metabolism can allow for greater toxin intake by offsetting the cost of toxin ingestion.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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