Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Journal ArticleDOI
Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy
Lucia Buccarello,Lucia Buccarello,Giuliano Grignaschi,Alessia Di Giancamillo,Cinzia Domeneghini,Roberto Cosimo Melcangi,Tiziana Borsello,Tiziana Borsello +7 more
TL;DR: Results suggest a sex dependent neuroprotective effect of LFPD in P301L-tg mice, suggesting that lifestyle intervention strategies may be clinically relevant for delaying the onset of cognitive impairment and dementia, especially in females.
Journal ArticleDOI
Complex relationship between amino acids, fitness and food intake in Bombus terrestris.
C. Ruth Archer,Johannes Fähnle,Maximilian Pretzner,Cansu Üstüner,Nina Weber,Andreas Sutter,Vincent Doublet,Lena Wilfert,Lena Wilfert +8 more
TL;DR: In this paper, the effect of amino acids to carbohydrates (AA:C) ratio on bumble bee fitness and food intake was investigated, and it was found that high AA intake increased body mass, which is positively correlated with multiple fitness traits in bumble bees.
Journal ArticleDOI
Study on the nutritional ecology of wild primates
Haitao Zhao,Xiaowei Wang,Brigitte Kreigenhofer,Xiaoguang Qi,Songtao Guo,Chengliang Wang,Jian Zhang,Jianqiang Zhao,Baoguo Li,Baoguo Li +9 more
TL;DR: The research content of nutritional ecology is expanded as well as the major models and descriptive methods applied in primate nutritional research, which allows for a comparison between predicted and observed patterns, and promotes the development of this subject.
Book ChapterDOI
The Nutritional Geometry of Aging
TL;DR: It is shown how the development of state-space geometric models in nutrition has provided a new approach to separating the effects of calories and nutrients and it is argued that similar geometric analysis is required for mammalian model systems.
Journal ArticleDOI
Effects of hunger on neuronal histone modifications slow aging in Drosophila
TL;DR: Weaver et al. as mentioned in this paper showed that hunger alone can also increase life span in fruit flies and that optogenetic stimulation of hunger neurons in the fruit fly brain extends life span.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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