Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Journal ArticleDOI
The role of plasticity in the evolution of cryptic pigmentation in a freshwater isopod.
Moritz D. Lürig,Rebecca J. Best,Rebecca J. Best,Marek Svitok,Marek Svitok,Jukka Jokela,Blake Matthews +6 more
TL;DR: The combined results of both experiments suggest that pigmentation of A. aquaticus is a developmentally plastic trait and that multiple environmental factors (e.g. macrophytes, diet and predation) might jointly influence the evolution of cryptic pigmentation in nature on relatively short time-scales.
Journal ArticleDOI
Neuronal processing of amino acids in Drosophila: from taste sensing to behavioural regulation
Naoko Toshima,Michael Schleyer +1 more
TL;DR: Focusing on recent studies in Drosophila, what is known so far about the perception of, and the behavioural responses to, amino acids in insects is summarized, and key questions for future research are identified.
Journal ArticleDOI
Three-dimensional diet regulation and the consequences of choice for weight and activity level of a marsupial carnivore
Shawn M. Wilder,Lihong Yuan,Cecile Roumilhac,David Raubenheimer,Stephen J. Simpson,Bronwyn M. McAllan +5 more
TL;DR: Increases in the intake of lipid, which is an important component in the diet of dunnarts, does not necessarily lead to increases in weight gain because these animals can adjust energy expenditure to balance their energy budget.
Journal ArticleDOI
Age‐related activity patterns are moderated by diet in Queensland fruit flies Bactrocera tryoni
TL;DR: Video recordings of Queensland fruit flies Bactrocera tryoni Froggatt that are maintained individually in cages are used to determine how diet affects the activity patterns (flight, walking, grooming, inactivity) of males and females at ages ranging from 4 to 30 days.
Posted ContentDOI
Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off
TL;DR: An automated video tracking setup is used to characterize how amino acid and reproductive states interact to shape exploitation and exploration decisions taken by adult Drosophila melanogaster, to achieve nutritional homeostasis and shows that the internal nutrient state defines the exploration-exploitation trade-off.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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