Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Journal ArticleDOI
Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila
Paul Vigne,Christian Frelin +1 more
TL;DR: It is concluded that flies sense and respond to specific nutrients and that food presentation is a major factor which determines the sensitivity of flies to dietary restriction.
Posted ContentDOI
The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins
TL;DR: The results suggest the effects of DR are not necessarily intrinsically pro-longevity and could be considered an escape from costs incurred under nutrient-rich conditions, in addition to novel, discrete costs associated with restricting dietary protein.
Journal ArticleDOI
Sprint speed is unaffected by dietary manipulation in trained male Anolis carolinensis lizards.
TL;DR: It is suggested that sprint speed is more canalized than either endurance or bite force in green anoles, and the hypothesis that the response to sprint training is sensitive to both the type and amount of resources in Anolis carolinensis is tested.
Journal ArticleDOI
Dietary protein restriction deciphers new relationships between lifespan, fecundity and activity levels in fruit flies Drosophila melanogaster
Sudhakar Krittika,Pankaj Yadav +1 more
TL;DR: It is found that lifespan under different protein concentrations remains unaltered, even though protein restricted diets exerted an age-specific influence on fecundity, and it is reported that not all concentrations of PR diet increase activity, suggesting that the correlation between lifespan and the lifetime activity can be challenged under protein-restricted condition.
Journal ArticleDOI
Offspring diet supersedes the transgenerational effects of parental diet in a specialist herbivore Neolema abbreviata under manipulated foliar nitrogen variability.
TL;DR: The results show conflicting responses to parental diet between larvae and adults of the same generation among an insect species with both actively feeding larval and adult life stages, suggesting limited sensitivity to parental diets in the adult stage.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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