Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Beyond calorie restriction: aging as a biological target for nutrient therapies
TL;DR: The conventional wisdom that emerged from first 50 years of rodent food restriction studies included (1) that the longevity impact of restriction was greater the longer restriction was imposed, and (2) restricting calories rather than any specific macronutrient was critical to its health and longevity benefits as mentioned in this paper.
Journal ArticleDOI
Condition-dependent interaction between mating success and competitive fertilization success in Drosophila melanogaster.
TL;DR: In this paper, the larval diet of male and female Drosophila melanogaster was manipulated to study how body size variation in both sexes biases competitive outcomes at different reproductive stages, from mating to paternity.
Journal ArticleDOI
Multidimensional approach to formulating a specialized diet for northern corn rootworm larvae
Man P. Huynh,Bruce E. Hibbard,Stephen L. Lapointe,Randall P. Niedz,B. Wade French,Adriano E Pereira,Deborah L. Finke,Kent S. Shelby,Thomas A. Coudron +8 more
TL;DR: An improved NCR diet formulation is validated that supports approximately 97% survival and molting, and a 150% increase in larval weight after 10 days of feeding compared with the best previously published artificial diet.
Journal ArticleDOI
Influence of Supplemental Protein on the Life Expectancy and Reproduction of the Chinese Citrus Fruit Fly, Bactrocera minax (Enderlein) (Tetradacus minax) (Diptera: Tephritidae).
Fulian Wang,Consolatha Chambi,Zaiyuan Li,Cong Huang,Yuekun Ma,Chuanren Li,Xiaohai Tian,Frank Sangija,Mbuya Sylvain Ntambo,Onésime M. Kankonda,Sumaira Hafeez,Toheed Anwar,Rahat Sharif +12 more
TL;DR: Based on the results, protein supplements enhanced B. minax survival, mating, and fecundity and deepens the understanding on its physiology that could be used to enhance the management of the pest.
Journal ArticleDOI
Insights into how development and life-history dynamics shape the evolution of venom.
Joachim M. Surm,Yehu Moran +1 more
TL;DR: Venomous animals are a striking example of the convergent evolution of a complex trait as mentioned in this paper, and they have independently evolved an apparatus that synthesizes, stores, and secretes a mixture of toxic compounds to the target animal through the infliction of a wound.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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